A rhythm control strategy based on a combination of antiarrhythmic drugs and electrical cardioversion(s) has emerged as a viable alternative for treatment of atrial fibrillation, particularly when the arrhythmia is associated with symptoms, which may be poorly tolerated, or with congestive heart failure. Several classes of antiarrhythmic drugs are available to restore sinus rhythm by chemical cardioversion and to help maintain it once it has been achieved. In our discussion, we will detail aspects of their efficacy and safety, and attempt to outline a pragmatic clinical approach to their use. Some newer drugs are currently under investigation and hold promise for improved efficacy and/or more favorable side effect profile and will be mentioned in this article.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pcad.2005.06.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep Neural Network Analysis of the 12-Lead Electrocardiogram Distinguishes Patients With Congenital Long QT Syndrome From Patients With Acquired QT Prolongation.
Mayo Clin Proc
January 2025
Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN; Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN. Electronic address:
Objective: To test whether an artificial intelligence (AI) deep neural network (DNN)-derived analysis of the 12-lead electrocardiogram (ECG) can distinguish patients with long QT syndrome (LQTS) from those with acquired QT prolongation.
Methods: The study cohort included all patients with genetically confirmed LQTS evaluated in the Windland Smith Rice Genetic Heart Rhythm Clinic and controls from Mayo Clinic's ECG data vault comprising more than 2.5 million patients.
Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women.
Nutrients
January 2025
Interdisciplinary Laboratory in Neurosciences, Physiology, and Psychology: Physical Activity, Health, and Learning (LINP2), UFR STAPS, Paris Nanterre University, 92000 Nanterre, France.
Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times of the day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women.
Methods: Random allocation of sixty-one participants into four groups: early time-restricted eating plus physical activity (ETRE-PA, n = 15, 31.8 ± 10.
Chronobiological Factors Influencing Glycemic Control and Birth Outcomes in Gestational Diabetes Mellitus.
Nutrients
December 2024
Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Background/objectives: Studies have shown that chronobiological factors may adversely affect glycemic control in patients with type 2 diabetes mellitus. We assessed the association of chronobiological factors with glycemic control and neonatal birth weight in women with GDM.
Methods: A prospective cohort study included 208 women aged 18-45 years with a singleton pregnancy who were randomly selected from among women undergoing follow-up for GDM at the Maternal-Fetal Medicine Unit of a tertiary medical center.
Stroke in Athletes with Atrial Fibrillation: A Narrative Review.
Diagnostics (Basel)
December 2024
Hospital de Santa Cruz, 2790-134 Lisbon, Portugal.
Atrial fibrillation (AF) is the most common sustained arrhythmia, linked with a significantly heightened risk of stroke. While moderate exercise reduces AF risk, high-level endurance athletes paradoxically exhibit a higher incidence. However, their stroke risk remains uncertain due to their younger age, higher cardiovascular fitness, and lower rate of comorbidities.
View Article and Find Full Text PDFChronic Dexamethasone Disturbs the Circadian Rhythm of Melatonin and Clock Genes in Goats.
Animals (Basel)
January 2025
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Article Synopsis
- Dex, a drug used for its immunosuppressive and anti-inflammatory effects, disrupts melatonin secretion and biological clock gene expression in goats.
- After 21 days of Dex treatment, goats showed significantly lower melatonin levels in both plasma and colon, as well as decreased expression of AANAT, a key enzyme for melatonin synthesis.
- The circadian rhythms of several clock genes were disrupted in the Dex group, along with notable changes in CLOCK and BMAL1 protein levels, indicating that chronic Dex exposure affects biological rhythm regulation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!