[The influence of induced hypertension in acute phase on focal cerebral ischemia injury].

Objective: To study the influence of induced hypertension in acute phase on the infarct volume and regional cerebral blood flow (rCBF) during focal cerebral ischemia in rats.

Methods: The adult rat's models of permanent focal cerebral ischemia were established by permanent middle artery occlusion. Thirty-six rats were divided six groups. The rCBF of cortical penumbra during focal cerebral ischemia was determined by Laser-Doppler Flowmetry. After experiment was over, the brain was TTC stained and the infarct volume was calculated by computer image analytic system.

Results: The rCBF was resumed by (81.8 +/- 3.1)%, (56.0 +/- 2.1) and (38.8 +/- 2.0)% in induced hypertension groups compared with the basic rCBF. The volume of infarction was (14 +/- 7) mm(3), (90 +/- 24) mm(3) separately in group induced hypertension after 2 and 3 hour ischemia. Induced hypertension during 3 hours could reduce infarct volume significantly.

Conclusion: To improve rCBF in penumbra may be one of protective mechanism of induced hypertension on brain ischemia.