[Effect of Ganoderma triterpene on proliferation of dendritic cells from mouse spleen].

Objective: To investigate the effect of Ganoderma Triterpene (GT) on proliferation of Dendritic cells (DC) from mouse spleen.

Methods: Compared with the cytokine (GM-CSF + IL-4), we investigated the effect of GT of different concentrations and cytokine + GT of different concentrations on proliferation of DC from mouse spleen by MTT.

Results: GT (40-200 microg/ml) could stimulate the proliferation of DC significantly, but the stimulations weren't obvious compared with the cytokine. GT + cytokine, compared with the negative control, had obviously promoting effect and was better than the cytokine. The results above indicated GT could not only stimulate the proliferation of DC but also significantly coorderate with the cytokine.

Conclusions: GT may play the role by its growth factor-like function, and by cooperating with the cytokine in the regulation of DC.