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New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors. | LitMetric
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New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.

W J Suling L E Seitz R C Reynolds W W Barrow

Antimicrob Agents Chemother

Southern Research Institution, Birmingham, Alabama, USA.

Published: November 2005

Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280141PMC
http://dx.doi.org/10.1128/AAC.49.11.4801-4803.2005DOI Listing

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