Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280177 | PMC |
| http://dx.doi.org/10.1128/AAC.49.11.4751-4753.2005 | DOI Listing |
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