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Background And Objectives: We are reporting the performance of HPV self-sample collected by a novel kit in comparison with clinician collected cervical sample for HPV testing for cervical cancer screening.

Methods: Consenting, eligible women aged 25 to 60, with a positive cervical cancer screening test report in the past one year but without any prior treatment for cervical abnormalities were enrolled in the study. Each woman provided 2 samples for the HPV test (vaginal self-sample collected with the CERVICHECKTM, an indigenous kit from India and cervical sample collected by the clinician).

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Systematic review of economic evaluations of triage tests for women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL).

Int J Technol Assess Health Care

November 2024

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

Article Synopsis
  • The study aimed to analyze cost-effectiveness of different triage tests for women with atypical squamous cells (ASC-US) or low-grade lesions (LSIL) compared to repeat cytology.
  • A systematic review identified five relevant cost-effectiveness analyses, focusing on tests such as HPV testing and immediate colposcopy, measuring their effectiveness by the detection of cervical intraepithelial neoplasia (CIN2+).
  • Findings indicate that HPV testing is often the most cost-effective triage method, while cytology is deemed the least effective despite being less expensive, suggesting a need for updated triage programs for better treatment and resource allocation.
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A novel ionic liquid-based approach for DNA and RNA extraction simplifies sample preparation for bacterial diagnostics.

Anal Bioanal Chem

December 2024

Institute of Chemical, Environmental and Bioscience Engineering, Working Area Molecular Diagnostics 166/5/3, IFA Tulln, TU Wien, Tulln, Austria.

Article Synopsis
  • DNA- and RNA-based diagnostics are crucial for detecting health-related bacteria, providing important information on their presence and treatment effectiveness.
  • A new extraction protocol using an ionic liquid and magnetic beads enables quick and easy molecular diagnostics by efficiently capturing nucleic acids without needing extensive materials.
  • This method demonstrates comparable or better performance than current commercial extraction kits, is cost-effective, requires minimal resources, and is suitable for rapid testing in various settings, promoting advancements in molecular diagnostics.
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Identification of cancer driver mutations in liquid-based cytology samples for the screening of endometrial diseases.

BJC Rep

November 2023

Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.

Background: Endometrial cancer (EC) is one of the leading causes of cancer death among women and early detection is crucial for its successful treatment. We previously showed that cytological examination combined with genetic analysis using liquid-based cytology (LBC) samples improved the diagnostic sensitivity of EC.

Methods: Among 218 individuals who underwent endometrial screening by LBC, 208 samples were analysed by cancer-panel sequencing.

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Introduction CINtec PLUS is a relatively recent method introduced in Romania for detecting cervical precancerous lesions. This technique utilizes simultaneous double immunostaining with p16 and Ki67 to identify potentially transformative human papillomaviruses (HPVs). CINtec PLUS has demonstrated superior sensitivity and specificity compared to conventional Papanicolaou (PAP) cytology and PAP liquid-based cytology, allowing for more accurate identification of HPV infections that may progress to malignancy among women with abnormal screening results.

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