AI Article Synopsis
- An 11-year-old boy with a serious Epstein-Barr virus infection successfully received a cord blood transplant after previous attempts with his mother's stem cells failed.
- The transplant used cells from an unrelated donor and was preceded by a rigorous conditioning treatment involving radiation and chemotherapy.
- After 15 months, the boy remains in complete remission with no signs of the virus, making this the first successful case of cord blood transplantation for this virus-related condition.
Article Abstract
An 11-year-old boy with severe chronic active Epstein-Barr virus infection (CAEBV) underwent successful cord blood transplantation (CBT) after consecutive failure of peripheral blood and bone marrow transplantation from his HLA-mismatched mother. CB cells from an unrelated donor were infused after conditioning with total body irradiation (12 Gy), melphalan (120 mg/m(2)), and etoposide (600 mg/m(2)). Complete remission without circulating EBV-DNA has continued for 15 months after a delayed hematologic recovery. This is the first successful report of CBT for CAEBV. CB may therefore be an alternate source of stem cells for the curative treatment of CAEBV, despite the absence of EBV-specific cytotoxic T lymphocytes.
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| http://dx.doi.org/10.1002/ajh.20430 | DOI Listing |
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