AI Article Synopsis
- EB1 is a microtubule protein that serves as a marker for dynamic microtubule plus ends and may also influence their behavior directly.
- There are many interactions between EB1 and other microtubule-binding proteins, suggesting there might be a unified mechanism for how EB1 operates.
- Recent studies indicate that EB1 is involved in communication between mitotic microtubules and actin filaments, hinting at its significant role in microtubule-based transport and the functionality of other microtubule-binding proteins.
Article Abstract
The EB1 protein is a member of the exciting and enigmatic family of microtubule (MT) tip-tracking proteins. EB1 acts as an exquisite marker of dynamic MT plus ends in some cases, whereas in others EB1 is thought to directly dictate the behavior of the plus ends. How EB1 differentiates between these two roles remains unclear; however, a growing list of interactions between EB1 and other MT binding proteins suggests there may be a single mechanism. Adding another layer of complexity to these interactions, two studies published in this issue implicate EB1 in cross-talk between mitotic MTs and between MTs and actin filaments (Goshima et al., p. 229; Wu et al., p. 201). These results raise the possibility that EB1 is a central player in MT-based transport, and that the activity of MT-binding proteins depends on their ability or inability to interact with EB1.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171192 | PMC |
| http://dx.doi.org/10.1083/jcb.200509150 | DOI Listing |
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