AI Article Synopsis
- Apigenin (Api) and tt-farnesol (Far) are two natural compounds that can help reduce harmful dental biofilms associated with cavities.
- When combined with fluoride (F), both Api and Far significantly boost F's effectiveness against the bacteria Streptococcus mutans, leading to reduced biofilm growth.
- Studies in rats showed that the combination of Api, Far, and F was especially effective in preventing cavities, performing similarly to a known antibacterial treatment, chlorhexidine, combined with F.
Article Abstract
Apigenin (Api) and tt-farnesol (Far) are two naturally occurring agents that affect the development of cariogenic biofilms. Fluoride (F) interferes physicochemically with caries development and also exhibits antibacterial activity. We examined whether the association of Api and Far enhance the anti-caries properties of F by acting cooperatively on the expression of virulence of Streptococcus mutans. The biological effects of each of the agents were greatly enhanced when used in combination with F. In general, biofilms treated with Api and/or Far in combination with F displayed less biomass and fewer insoluble glucans and iodophilic polysaccharides than did those treated with the test agents alone (P < 0.05). The combination of the test agents with F was highly effective in preventing caries development in rats, especially Api+Far+F, and results were comparable with those observed with chlorhexidine + F (positive control). Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490022 | PMC |
| http://dx.doi.org/10.1177/154405910508401109 | DOI Listing |
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Purpose: To characterize experimental adhesives containing natural antimicrobial agents (proanthocyanidins, apigenin, tt-farnesol) in the primer and to evaluate their anti-caries effect.
Materials And Methods: Natural agents were incorporated in the primer of an experimental adhesive: 4.5% proanthocyanidins (PA), 1 mM apigenin (API), 1 mM apigenin + 5 mM tt-farnesol (API + FAR), and primer without antimicrobial agent (control).
Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.
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Department of Biomaterials and Biomechanics, School of Dentistry, Oregon Health & Science University, Portland, OR, USA. Electronic address:
Article Synopsis
- The study aimed to evaluate the effect of Apigenin and tt-Farnesol on reducing the harmfulness of Streptococcus mutans in resin composites and cements used in dental restorations.
- The researchers tested various combinations of these anti-caries agents along with fluoride, assessing their impact on bacterial growth, biofilm characteristics, and the physical properties of the materials over three years.
- Results showed that while these agents diminished certain bacterial components, they did not significantly alter the viability of the bacteria or the essential properties of the composites.
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Objectives: The aim of this in vitro study was to analyze the effect of the incorporation of two anti-caries agents into dental adhesives on the reduction of the virulence of Streptococcus mutans and on the adhesion to dentin.
Methods: Apigenin (1mM) and tt-Farnesol (5mM) were added separately and in combination to a self-etch adhesive (CS3 - Clearfil S3 Bond Plus) and to an each-and-rinse adhesive (OPT - OptiBond S). Biofilm of S.
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Caries is the most common oral infectious disease in the world. Its development is influenced also by diet components that interfere with pathogen mutans group Streptococci (MGS) activity. A very active research to identify functional foods and their components that are generally recognised as safe has been ongoing, with the aim of developing alternative approaches, to the use of synthetic chlorhexidine, and at the reduction or prevention of caries.
View Article and Find Full Text PDFApigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries.
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Center for Oral Biology and Eastman Dept. of Dentistry, University of Rochester Medical Center, 625 Elmwood Avenue, Box 683, Rochester, NY 14620, USA.
Article Synopsis
- Apigenin (Api) and tt-farnesol (Far) are two natural compounds that can help reduce harmful dental biofilms associated with cavities.
- When combined with fluoride (F), both Api and Far significantly boost F's effectiveness against the bacteria Streptococcus mutans, leading to reduced biofilm growth.
- Studies in rats showed that the combination of Api, Far, and F was especially effective in preventing cavities, performing similarly to a known antibacterial treatment, chlorhexidine, combined with F.
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