Purpose: To study the internal diameter of the anterior chamber (AC), which remains a relatively subjective procedure dominated by the white-to-white technique, evaluated with a compass or using anterior segment photographs. In vivo dimensions of the AC were studied with an optical coherence tomographer (AC OCT) prototype.
Setting: Clinique Monticelli, Marseilles, France.
Methods: The dimensions in 107 normal eyes that had never had surgery were studied with the IOLMaster and AC OCT.
Results: The mean anterior chamber depth was 3.53 mm +/- 0.35 (SD) with the IOLMaster (Carl Zeiss, Medictec) and 3.64 +/- 0.33 mm with the AC OCT (Carl Zeiss, Medictec). The mean horizontal diameter of the AC was 12.12 +/- 0.44 mm with the IOLMaster and 12.20 +/- 0.44 mm with the AC OCT. With the AC OCT, the anterior chamber's horizontal and vertical diameter could be evaluated; in 74% of the observed eyes, the vertical diameter was larger by at least 100 mum than the horizontal diameter.
Discussion: The AC OCT has better reproducibility than the IOLMaster for evaluating the depth or internal diameter of the anterior chamber. This study showed that in 74% of cases, the AC was an oval with a larger vertical axis, which provides evidence of the value of the OCT preoperative examinations for phakic intraocular lens implantation.
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http://dx.doi.org/10.1016/j.jcrs.2005.02.030 | DOI Listing |
Int J Mol Sci
January 2025
Department of Ophthalmology, Penn State University, Hershey, PA 17033, USA.
Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, and molecular composition of released EVs correlate to the cells of origin, modulated by the cell's environment and pathologic state. The proteins, DNA, RNA, and protein cargo carried by EVs are protected by degradation, with a prominent role in targeted intercellular signaling.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke-shi 329-0498, Tochigi, Japan.
Aflibercept and brolucizumab, two anti-VEGF agents used as intravitreal injections in ophthalmology, differ significantly in molecular weight (aflibercept-115 kDa and brolucizumab-26 kDa). Using aqueous humor samples collected after drug administration, we measured and performed a comparative analysis of pharmacokinetics and half-lives of these drugs in the human eye. Since the quantification of monoclonal antibodies (mAbs) using antigen-antibody reactions, such as ELISA, is influenced by endogenous ligands or anti-drug antibodies, we employed nano-surface and molecular-orientation limited proteolysis (nSMOL), combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS), for accurate measurements.
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Cardiovascular Institute "Dedinje", 111040 Belgrade, Serbia.
Coronary artery fistulas (CAFs) are rare congenital anomalies, presenting in 0.05-0.9% of cases, characterized by an aberrant connection between a coronary artery and a cardiac chamber or great vessel.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
Institute for Vision Research, University of Iowa, Iowa City, IA, United States.
Background: Endothelin is a potent vasoconstrictor and contributes to the regulation of vascular perfusion. Aberrant endothelin-1 (ET-1) levels in aqueous humor have been reported across a variety of vascular diseases of the eye, including glaucoma. These findings suggest that dysregulation of ET-1 production may contribute to glaucoma pathophysiology.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
UCL Institute of Ophthalmology, University College London, London, UK.
Purpose: A human model able to simulate the manifestation of corneal endothelium decompensation could be advantageous for wound healing and future cell therapy assessment. The study aimed to establish an ex vivo human cornea endothelium wound model where endothelium function can be evaluated by measuring corneal thickness changes.
Methods: The human cornea was maintained in an artificial anterior chamber, with a continuous culture medium infusion system designed to sustain corneal endothelium and epithelium simultaneously.
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