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Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells. | LitMetric
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Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells.

Mi-Hyun Hwang Jong-Hwan Lim Hyo-In Yun Man-Hee Rhee Jae-Youl Cho Walter H Hsu Seung-Chun Park

Biotechnol Lett

Laboratory of Veterinary Pharmacology & Toxicology, College of Veterinary Medicine, Kyungpook National University, 702-701, Daegu, Republic of Korea.

Published: October 2005

The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 microg ml(-1))-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1beta and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 microg ml(-1 )inhibited the LPS-induced increase in the transcription of IL-1beta and iNOS and nitric oxide (NO) production in a dose-dependent manner.

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http://dx.doi.org/10.1007/s10529-005-2515-1DOI Listing

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