The direct alpha-zincation of amides, phosphonates and phosphine oxides by H-Zn exchange.

Chem Commun (Camb)

Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA.

Published: November 2005

Stoichiometric or catalytic quantities of simple 2 degrees amines greatly increase the rate of H-Zn exchange between ZnPh2 and a range of relatively non-acidic substrates, allowing for the convenient and direct preparation of alpha-functionalized organozincs.

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http://dx.doi.org/10.1039/b509190jDOI Listing

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