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Effect-based analysis of endocrine effects in surface and ground water with focus on progestagenicity using Arxula yeast-based reporter gene assays.
Environ Toxicol Chem
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Institut für Umwelt & Energie, Technik & Analytik e. V. (IUTA), Duisburg, Germany.
The use of effect-based methods in water monitoring for identifying risks to aquatic organisms and human health is important for aiding regulatory decisions. In the past decades, the database on monitoring, especially in surface waters, has grown as this aquatic environment is openly exposed to various contamination sources. With regard to endocrine disruption, estrogenic and androgenic effects have been primarily investigated.
View Article and Find Full Text PDFDNA strand breaks in the crab Carcinus aestuarii exposed to three BPA analogues and their mixture.
Mar Pollut Bull
January 2025
Department of Biology, University of Padova, Via Bassi 58/B, 35131 Padova, Italy.
In this study, the genotoxic effects of three different bisphenols (BPAF, BPF and BPS) and their mixture were assessed in the crab Carcinus aestuarii. Crabs were exposed for 7 and 14 days to 300 ng/L of BPA analogues, alone or as a mixture (100 ng/L for each compound). After 7- and 14-day exposure, gills and hepatopancreas were sampled from crabs to evaluate damage to DNA by quantifying the levels of DNA single- and double-strand breaks.
View Article and Find Full Text PDFMapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing.
ALTEX
January 2025
In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.
On occasion of the DNT5 meeting in Konstanz, Germany (April-2024), participants brainstormed on future challenges concerning a regulatory implementation of the developmental neurotoxicity (DNT) in vitro test battery (DNT-IVB). The five discussion topics below outline some of the key issues, opportunities and research directions for the next several years: (1) How to contextualize DNT hazard with information on potential maternal toxicity or other toxicity domains (non-DNT)? Several approaches on how to use cytotoxicity data from NAMs were discussed. (2) What opportunities exist for an immediate or near-future application of the DNT-IVB, e.
View Article and Find Full Text PDFDynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics.
Environ Int
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Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, 210009, China.
Polystyrene nanoplastics (PS-NPs) are omnipresent in the air and can be inhaled by humans. However, their long-term adverse implications and toxicological mechanisms for human respiratory health are unclear. Therefore, this study aims to provide new insights into the pulmonary toxicity of PS-NPs using mice and organoid models.
View Article and Find Full Text PDFOral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system.
Sci Adv
January 2025
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, People's Republic of China.
Acute alcohol intoxication could cause multiorgan damage, including nervous, digestive, and cardiovascular systems, and in particular, irreversible damage to the brain and liver. Emerging studies have revealed that the endogenous multienzymatic antioxidant defense system (MEAODS) plays a central role in preventing oxidative stress and other toxicological compounds produced by alcohol. However, few available drugs could quickly regulate MEAODS.
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