Sporeamicin A is a new erythromycin-type antibiotic isolated from a species of Saccharopolyspora. It was active in vitro against a wide variety of Gram-positive bacteria. In vitro studies indicated that the sporeamicin A was stable in the presence of human serum, although it was bound to serum proteins. Sporeamicin A was effective in the mouse protection test against Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Sporeamicin A attained higher plasma and tissue levels in the rat than did erythromycin stearate.
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Sporeamicin A, a new macrolide antibiotic. III. Biological properties.
J Antibiot (Tokyo)
May 1992
Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
Sporeamicin A is a new erythromycin-type antibiotic isolated from a species of Saccharopolyspora. It was active in vitro against a wide variety of Gram-positive bacteria. In vitro studies indicated that the sporeamicin A was stable in the presence of human serum, although it was bound to serum proteins.
View Article and Find Full Text PDFSporeamicin A, a new macrolide antibiotic. II. Structure determination.
J Antibiot (Tokyo)
May 1992
Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
Structure of a novel antibiotic, sporeamicin A (SRM-A), was determined by a combination of spectroscopic and X-ray crystallographic studies. SRM-A has a unique structure containing a 2,3-dihydro-3-oxofuran moiety as part of a 14-membered macrolide ring.
View Article and Find Full Text PDFSporeamicin A, a new macrolide antibiotic. I. Taxonomy, fermentation, isolation and characterization.
J Antibiot (Tokyo)
May 1992
Research Labolatories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
Sporeamicin A, a novel antibiotic, was isolated from the culture filtrate of an actinomycete. The producing organism, strain L53-18, was taxonomically assigned as a species of the genus Saccaropolyspora. The antibiotic was extracted with chloroform and was then purified by crystallization.
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