Aim: To evaluate the diagnostic potential of the new vacuum-assisted method VacuFlash (VF) in clinical routine of breast diagnostics.
Method: From april 2002 to march 2003, the new sonographically guided vacuum-assisted system VacuFlash was used in 75 patients with a BI-RADS 5 lesion (analogue). The patients were aged between 31-75 yrs (median: 51 yrs), the size of the lesions measured 8-33 mm (median: 14 mm). 5 specimens were taken from each lesion.
Results: In 69 of the 75 lesions (92 %, respectively), malignancy was confirmed. In 8 lesions (8 %, resp.), we found a benign histology, confirmed by consecutive surgery.
Conclusion: The new vacuum-assisted device VacuFlash is a technically perfected and applicable diagnostic method. Especially in the view of the cost it has to be compared with high-speed core cut biopsy, the hand-held Mammotome system and open surgical biopsy. High-speed core cut biopsy seems to be the standard procedure in diagnostic percutaneous breast intervention to clarify sonographically detected breast lesions.
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http://dx.doi.org/10.1055/s-2005-858647 | DOI Listing |
Sensors (Basel)
January 2025
School of Aeronautics and Astronautics, University of Electronic Science and Technology of China, Chengdu 611731, China.
Target detection is a core function of integrated sensing and communication (ISAC) systems. The traditional likelihood ratio test (LRT) target detection algorithm performs inadequately under low signal-to-noise ratio (SNR) conditions, and the performance of mainstream orthogonal frequency division multiplexing (OFDM) waveforms declines sharply in high-speed scenarios. To address these issues, an information-theory-based orthogonal time frequency space (OTFS)-ISAC target detection processing framework is proposed.
View Article and Find Full Text PDFbioRxiv
January 2025
Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston MA 02115.
The concentrations of extracellular and intracellular signaling molecules, such as dopamine and cAMP, change over both fast and slow timescales and impact downstream pathways in a cell-type specific manner. Fluorescence sensors currently used to monitor such signals are typically optimized to detect fast, relative changes in concentration of the target molecule. They are less well suited to detect slowly-changing signals and rarely provide absolute measurements of either fast and slow signaling components.
View Article and Find Full Text PDFProtein translocation across cellular membranes is an essential and nano-scale dynamic process. In the bacterial cytoplasmic membrane, the core proteins in this process are a membrane protein complex, SecYEG, corresponding to the eukaryotic Sec61 complex, and a cytoplasmic protein, SecA ATPase. Despite more than three decades of extensive research on Sec proteins, from genetic experiments to cutting-edge single-molecule analyses, no study has visually demonstrated protein translocation.
View Article and Find Full Text PDFSensors (Basel)
December 2024
School of Data Science and Technology, North University of China, Taiyuan 030051, China.
Blades are the core components of rotating machinery, and the blade vibration status directly impacts the working efficiency and safe operation of the equipment. The blade tip timing (BTT) technique provides a solution for blade vibration monitoring and is currently a prominent topic in research on blade vibration issues. Nevertheless, the non-stationary factors present in actual engineering applications introduce inaccuracies in the BTT technique, resulting in blade vibration measurement errors.
View Article and Find Full Text PDFPharmaceutics
December 2024
AbbVie Deutschland GmbH & Co. KG, Knollstraße, 67061 Ludwigshafen am Rhein, Germany.
Atomization plays a key role in spray drying, a process widely used in the pharmaceutical, chemical, biological, and food and beverage industries. In the pharmaceutical industry, spray drying is particularly important in the preparation of amorphous solid dispersions, which enhance the bioavailability of active pharmaceutical ingredients when mixed with a polymer. In this study, a 3D-printed adaptation of a commercial spray dryer nozzle (PHARMA-SD PSD-1, GEA Group AG) was used to investigate the atomization of PVP-VA 64 polymer solutions under varying flow conditions using high-speed diffuse back-illumination.
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