AI Article Synopsis
- Previous studies found that olanzapine helps reduce alcohol cravings, particularly in people with the seven-repeat allele of the DRD4 gene.
- The current study explored how olanzapine impacts craving induced by cues in a 12-week trial with participants having and not having this allele.
- Results indicated that those with the seven-repeat allele experienced significant reductions in cue-driven cravings and overall alcohol use when treated with olanzapine, unlike those with shorter alleles who didn’t benefit as much.
Article Abstract
Previous studies have indicated that olanzapine decreases craving after a priming dose of alcohol, that craving after a priming dose of alcohol is greater among individuals with the seven-repeat allele of the DRD4 variable number of tandem repeats (VNTR) polymorphism, and that the effect of olanzapine (a D2/D4 antagonist) is more pronounced among individuals with this allele. The present study tested the hypothesis that olanzapine may be differentially effective at reducing cue-elicited craving and differentially effective as a treatment for alcohol dependence over the course of a 12-week, randomized, placebo-controlled trial among individuals with and without the seven-repeat allele. Participants who met DSM IV criteria for alcohol dependence were randomly assigned to receive olanzapine (5 mg) or a placebo over the course of the trial. After 2 weeks of treatment, participants completed a cue reactivity assessment. The results suggested that participants who were homozygous or heterozygous for the seven (or longer)-repeat allele of the DRD4 VNTR responded to olanzapine with reductions in cue-elicited craving as well as reductions in alcohol consumption over the course of the 12-week trial, whereas individuals with the shorter alleles did not respond favorably to olanzapine.
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| http://dx.doi.org/10.1038/sj.npp.1300917 | DOI Listing |
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