AI Article Synopsis
- The study focuses on using specific enzymes called NADPH-dependent ketoreductases to effectively reduce alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters.
- This biocatalytic method results in the production of optically pure keto alcohols and hydroxy esters, which are important compounds in organic chemistry.
- The technique demonstrated efficiency, indicating that these enzymes can streamline the synthesis of these desired compounds.
Article Abstract
[reaction: see text] The biocatalytic reduction of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.
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| http://dx.doi.org/10.1021/ol051166d | DOI Listing |
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