AI Article Synopsis
- - The study aimed to understand the role of substance P (SP) in patients with chronic obstructive pulmonary disease (COPD) and asthma compared to healthy individuals.
- - Researchers compared SP levels in plasma and sputum samples from COPD patients, asthmatic patients, and healthy subjects, finding significantly higher SP levels in both COPD and asthma patients than in healthy individuals.
- - The findings suggest that substance P may play a role in airway inflammation for both COPD and asthma, although SP levels were similar in COPD and asthma patients.
Article Abstract
Objective: To investigate the role of substance P (SP) in chronic obstructive pulmonary disease (COPD) or asthma.
Method: Plasma and sputum samples were obtained from 26 COPD patients and 20 asthmatic patients as well as 12 healthy subjects for measurement of SP content.
Results: Patients with COPD had significantly higher levels of SP in the plasma (7.9+/-2.6 pmol/L) and sputum (53.8+/-12.5 pmol/L) than the healthy subjects (3.6+/-1.7 pmol/L and 6.2+/-2.3 pmol/L, respectively, P<0.01). The asthmatic patients also had significantly higher SP levels (8.3+/-3.1 pmol/L and 46.9+/-10.2 pmol/L, respectively) than the healthy subjects, but there was no significant difference between COPD and asthmatic patients (P>0.05).
Conclusion: SP may be involved in the airway inflammation process in COPD and asthma.
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