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Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives.
Mol Med
January 2025
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran.
Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic stem cell transplantation (HSCT), thus increasing the risk of relapse and mortality. Single-cell RNA sequencing (scRNA-seq) will enable the classification of AML and guide treatment approaches by profiling patients with different facets of the same disease, stratifying risk, and identifying new potential therapeutic targets at the time of diagnosis or after treatment.
View Article and Find Full Text PDF[What holds the hospital together-A "fixation error" in terms of patient safety].
Anaesthesiologie
January 2025
Team Pflegewissenschaft und -fortschritt, Agaplesion Diakonieklinikum Hamburg, Hohe Weide 17, 20259, Hamburg, Deutschland.
Background: Fixation plasters are nowadays an important part of clinical care and the product range is adapted to the needs of patient care. A multifaceted selection is available.
Aim Of The Study: To increase vigilance towards the supposedly low-threshold use of fixation plasters in patient care.
Shaping the future of MRI in upper abdominal imaging: The promise of deep learning reconstruction.
Diagn Interv Imaging
January 2025
Medical Imaging Department, Henri Mondor Hospital, APHP, 94000, Créteil, France; Institut Mondor de la Recherche Biomédicale (IMRB) Team 18, INSERM Unit 955, Henri Mondor Hospital, 94000, Créteil, France.
Mortality and diurnal temperature range in Virginia.
Int J Biometeorol
January 2025
Southeast Regional Climate Center, Department of Geography and Environment, University of North Carolina, Chapel Hill, NC, 27514, USA.
The relationship between diurnal temperature range (DTR) and daily mortality from 2005 to 2020 is examined for seven large metropolitan areas in Virginia using distributed lag non-linear models that control for temperature and humidity. The relative risk of mortality increases for very high DTR, and there is a short lag effect of several days. High risk DTR days are rare, typically occurring less than 1% of the time at most locations.
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