Eastwood discusses a new study in that suggests that overexpression of the gene, leading to disruption of NMDA receptor function, may be important in the etiology of severe mental illnesses.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1261515 | PMC |
http://dx.doi.org/10.1371/journal.pmed.0020348 | DOI Listing |
BMC Genomics
December 2024
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, 528225, P.R. China.
Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified. To investigate the key metabolites affecting the quality of capons and the key regulatory mechanisms, Qingyuan partridge roosters were subjected to castration.
View Article and Find Full Text PDFNat Cardiovasc Res
December 2024
Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
The basic helix-loop-helix transcription factor HAND2 has multiple roles during vertebrate organogenesis, including cardiogenesis. However, much remains to be uncovered about its mechanism of action. Here, we show the generation of several hand2 mutant alleles in zebrafish and demonstrate that dimerization-deficient mutants display the null phenotype but DNA-binding-deficient mutants do not.
View Article and Find Full Text PDFInt J Mol Sci
August 2024
Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Low or insufficient testosterone levels caused by caponization promote fat deposition in animals. However, the molecular mechanism of fat deposition in caponized animals remains unclear. This study aimed to investigate the metabolomics and transcriptomic profiles of adipose tissues and study the effect of testosterone and leptin on the proliferation of adipocytes.
View Article and Find Full Text PDFJ Allergy Clin Immunol
September 2024
Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom. Electronic address:
Brain
November 2024
Key Laboratory of Developmental Genes and Human Diseases, MOE, Department of Histology and Embryology, Department of Pharmacy, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
The implication of 5-hydroxytryptamine 2C receptor (5-HT2CR) activity in depression is a topic of debate, and the underlying mechanisms remain largely unclear. Here, we elucidate how hippocampal excitation-inhibition (E/I) balance underlies the regulatory effects of 5-HT2CR in depression. Molecular biological analyses showed that chronic mild stress (CMS) reduced the expression of 5-HT2CR in hippocampus.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!