In time-resolved and spatially resolved experiments, singlet molecular oxygen, O2(a1Deltag), was created in a single nerve cell upon irradiation of a sensitizer incorporated in the cell using a focused laser beam. The singlet oxygen thus produced was detected by its infrared phosphorescence. Data obtained indicate that in both the cytoplasm and the nucleus of the cell, this reactive species is approximately 1-2 orders of magnitude longer-lived than previously believed. The data demonstrate that deactivation of singlet oxygen in the cell is dominated by interactions with the solvent not cellular constituents such as proteins. These results provide a new perspective for mechanistic studies of the role of O2(a1Deltag) in photoinduced cell death and intracellular signaling.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja055342p | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Catalytic degradation of diclofenac by ZnO-CoO: identification of major intermediates and degradation pathway.
Environ Sci Pollut Res Int
January 2025
Centre de Recherche Scientifique Et Technique en Analyses Physico-Chimiques, CP 42004, Bou-Ismail, Tipaza, Algeria.
ZnO-CoO material was successfully synthesized by the co-precipitation method and used as a catalyst for the removal of diclofenac sodium (DCF). ZnO-CoO exhibited higher catalytic activity in the catalytic process compared to the photocatalytic processes. Under optimum conditions, the activation of peroxymonosulfate (PMS) by ZnO-CoO achieved approximately 99% removal of DCF, confirming the effective adsorption and activation of PMS.
View Article and Find Full Text PDFReactive Oxygen Species Resistive Redox Mediator in Lithium-Oxygen Batteries.
Adv Mater
January 2025
School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea.
The utilization of redox mediators (RMs) in lithium-oxygen batteries (LOBs) has underscored their utility in high overpotential during the charging process. Among the currently known RMs, it is exceptionally challenging to identify those with a redox potential capable of attenuating singlet oxygen (O) generation while resisting degradation by reactive oxygen species (ROS), such as O and superoxide (O ). In this context, computational and experimental approaches for rational molecular design have led to the development of 7,7'-bi-7-azabicyclo[2.
View Article and Find Full Text PDFModeling synergy and individual effects of X-ray induced photodynamic therapy components.
Sci Rep
January 2025
Department of Medical Physics, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran.
X-ray induced photodynamic therapy (XPDT) utilizes self-lighting nanoparticles to combine the benefits of radiotherapy and photodynamic therapy. These nanomaterials transform X-ray to visible light that can be absorbed by nearby photosensitizers and in the presence of surrounding oxygen molecules generates reactive oxygen species, which are very toxic to the cells. Despite many studies conducted on modelling XPDT, little focused on the contribution of each component as well as their synergy effects.
View Article and Find Full Text PDFUnravelling the influence of structure on the optical properties of a pair of aza-BODIPY isomers and their application in photodynamic therapy.
J Mater Chem B
January 2025
Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang, China.
A pair of aza-BODIPY isomers, 1,7-di--butyl-3,5-dinaphthyl (Nap-BDP) and 1,7-dinaphthyl-3,5-di--butyl (revNap-BDP), were prepared in this study. According to the single crystal X-ray analysis, Nap-BDP exhibited an orthogonal structure. Owing to the difference in orthogonality and -Bu rotation between Nap-BDP and revNap-BDP, their spectral performances, including maximum absorption and emission, full width at half maximum, fluorescence quantum yield, photostability, singlet oxygen generation and photothermal conversion efficiency, were obviously different.
View Article and Find Full Text PDFFluorination of Aza-BODIPY for Cancer Cell Plasma Membrane-Targeted Imaging and Therapy.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China.
Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional PSs specifically designed for cancer PDT by fluorinating aza-BODIPY with perfluoro--butoxymethyl (PFBM) groups.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!