Objective: The aim of the current study was to test the influence of topiramate on behavior, body weight, and health-related quality of life (HRQOL) in bulimic patients.

Method: Thirty patients with bulimia nervosa were treated with topiramate in a 10-week randomized, double-blind, placebo-controlled study. The subjects were randomly assigned to receive topiramate (topiramate group [TG]; n = 30) or a placebo (control group [CG]; n = 30). Primary outcome measures were changes in the frequency of binging/purging, in body weight, and on the SF-36 Health Survey (SF-36) scales.

Results: In comparison to the CG group (according to the intent-to-treat principle), significant changes in the frequency of binging/purging (a > 50% reduction: TG, n = 11 [36.7%]; CG, n = 1 [3.3%]; p < .001), body weight (difference in weight loss between the two groups: 3.8 kg, 95% confidence interval [CI] = -5.4 to -2.1; p < .001), and SF-36 (all ps < .001) could be seen. All patients tolerated topiramate well.

Conclusion: Topiramate appears to safe and effective in influencing the frequency of binging/purging, body weight, and HRQOL in bulimic patients.

Download full-text PDF

Source
http://dx.doi.org/10.1002/eat.20202DOI Listing

Publication Analysis

Top Keywords

body weight
16
frequency binging/purging
12
bulimia nervosa
8
randomized double-blind
8
double-blind placebo-controlled
8
hrqol bulimic
8
changes frequency
8
binging/purging body
8
topiramate
7
weight
5

Similar Publications

Gut microbial communities and transcriptional profiles of black soldier fly (Hermitia illucens) larvae fed on fermented sericulture waste.

Waste Manag

January 2025

Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology/ Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Hechi University, Hechi 546300, China. Electronic address:

Sericulture waste poses significant challenges to industrial and environmental safety. Black soldier fly larvae (BSFL) offer a promising solution for organic waste management by converting it into insect protein. This study aimed to develop a microbial fermented method for utilizing sericulture waste to feed BSFL and explore the underlying mechanisms.

View Article and Find Full Text PDF

Passive heating in sport: Context specific benefits, detriments, and considerations.

Appl Physiol Nutr Metab

January 2025

Coventry University, Centre for Sport Exercise and Life Sciences, Coventry, Warwickshire, United Kingdom of Great Britain and Northern Ireland;

Exercise and passive heating share some acute physiological responses. These include increases in body temperature, sweat rate, blood flow, heart rate, and redistribution of plasma and blood volume. These responses can vary depending on the heating modality or dose (e.

View Article and Find Full Text PDF

Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice.

Am J Physiol Heart Circ Physiol

January 2025

Department of Biochemistry and Molecular Biology, Dalhousie University, Dalhousie Medicine New Brunswick, 355 Campus Ring Road, Saint John, New Brunswick, E2L 4L5, Canada.

Lipid phosphate phosphatase 3 (LPP3) is a membrane-bound enzyme that hydrolyzes lipid phosphates including the bioactive lipid, lysophosphatidic acid (LPA). Elevated circulating LPA production and cellular LPA signaling are implicated in obesity-induced metabolic and cardiac dysfunction. Deletion of LPP3 in the cardiomyocyte increases circulating LPA levels and causes heart failure and mitochondrial dysfunction in mice.

View Article and Find Full Text PDF

With the growing need for sustainable transportation solutions, understanding the relationship between driving characteristic parameters, vehicle type, and their impact on emissions and fuel consumption over real driving scenarios is becoming increasingly important. In this paper, four conventional vehicles and one hybrid vehicle with different technologies were compared in four distinct routes in Tehran city. Nineteen real driving cycles were generated using widely employed K-means and PCA algorithms.

View Article and Find Full Text PDF

Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder marked by repeated episodes of partial or complete upper airway obstruction during sleep, which leads to intermittent hypoxia and fragmented sleep. These disruptions negatively impact cardiovascular health, metabolic function, and overall quality of life. Obesity is a major modifiable risk factor for OSA, as it contributes to both anatomical and physiological mechanisms that increase the likelihood of airway collapse during sleep.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!