The use of polymethyl methacrylate has revolutionized surgical technique in total joint arthroplasty. In addition, in an effort to reduce the rate of infections as well as to treat active infections, the practice of adding powdered antibiotics to the cement has become commonplace. A simple and efficient technique of mixing antibiotic powder into cement that creates a uniform distribution of antibiotic is introduced. In addition, this process reduces the presence of "antibiotic voids," which, if present can alter the physical properties of the cement itself.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.arth.2005.07.001 | DOI Listing |
Clin Orthop Relat Res
October 2024
Rush Copley Medical Center, Aurora, IL, USA.
Background: Polymethylmethacrylate (PMMA) antibiotic-laden bone cement (ALBC) is commonly used in total joint arthroplasty to treat and potentially prevent prosthetic joint infection (PJI). Multiple properties impact the elution characteristics of antibiotics from PMMA-based ALBC, including viscosity. What is not known is how medium-viscosity cement formulations affect antibiotic elution and how different cement products from different manufacturers compare regarding reaching the minimum inhibitory concentration (MIC) of antibiotics for common PJI-causing organisms in an in vitro setting.
View Article and Find Full Text PDFJ Bone Jt Infect
March 2024
International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
: Osteomyelitis is a challenging bone infection associated with ischemia, trauma, or various surgical procedures (e.g., joint reconstruction).
View Article and Find Full Text PDFJ Arthroplasty
September 2024
Department of Orthopedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
Background: Periprosthetic joint infection (PJI) can be a serious complication of total knee arthroplasty (TKA). A method believed to decrease the incidence of PJI is antibiotic-laden bone cement (ALBC). Current clinical practice guidelines do not recommend ALBC in primary TKA.
View Article and Find Full Text PDFFoot Ankle Spec
March 2024
Sinai Health System, Baltimore, Maryland.
Pin tract infections are virtually universal complications with the use of external fixation. While most are superficial and respond to oral antibiotics and local care, septic loosening may occur at the bone-pin interface, which may lead to instability of the fixator, catastrophic failure, fracture, and long-term osteomyelitis. Classification systems and prevention protocols have been developed to address this ubiquitous complication.
View Article and Find Full Text PDFJBJS Essent Surg Tech
May 2023
Musculoskeletal Oncology Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Background: The Reconstructive Allograft Preparation by Toronto Sarcoma (RAPTORS) protocol is reliable and reproducible without substantially adding to the surgical reconstruction time or cost. Our technique includes clearance of debris, lavage of the medullary canal, pressurized filling of the medullary canal with antibiotic-laden cement for its mechanical and antimicrobial properties, and insertion of cancellous autograft at the allograft-host junctional ends prior to dual-plate compression to fix the allograft into the defect. Our experience with large intercalary allograft reconstruction has demonstrated high rates of long-term success and addresses the most common causes of large allograft failure (infection, fracture, and nonunion), as shown in our long-term outcome study.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!