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Chronic Myelomonocytic Leukemia with Central Nervous System Involvement in a Dog.
J Am Anim Hosp Assoc
January 2025
From Veterinary Neurological Center "La Fenice," Selargius, Italy (I.T., F.T., A.G.).
An 8 yr old, male, mixed-breed dog was presented with a 2 mo history of progressive weakness, worsened in the last 2 days before examination. Neurological examination revealed ambulatory tetraparesis, ataxia, and proprioceptive deficits in all four limbs. Menace response was reduced in the right eye and discomfort was detected on neck manipulation.
View Article and Find Full Text PDFSingle-cell dissection of multifocal bladder cancer reveals malignant and immune cells variation between primary and recurrent tumor lesions.
Commun Biol
December 2024
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Life Sciences and Technology, Tongji University, 200092, Shanghai, China.
Bladder carcinoma (BLCA) is characterized by a high rate of post-surgery recurrence and multifocality. Multifocal tumors have a higher risk of recurrence compared to single tumors, significantly impacting bladder cancer-specific mortality. However, the interregional or intraregional heterogeneity within both primary and recurrent tumors remains poorly understood.
View Article and Find Full Text PDFClinical presentation, diagnostic findings and short-term outcome in French bulldogs with presumptive spinal only meningoencephalomyelitis of unknown origin: 15 cases (2016-2023).
J Small Anim Pract
December 2024
Department of neurology, CHV Pommery, Reims, France.
Article Synopsis
- The study aimed to examine the clinical presentation, diagnosis, and outcomes of spinal only meningoencephalomyelitis (so-AME) of unknown origin in French bulldogs and compare it to intervertebral disc herniation in the same breed.
- A total of 15 French bulldogs were diagnosed with so-AME, with chronic onset symptoms common, primarily showing signs like ambulatory paresis and proprioceptive ataxia, while spinal pain was rare.
- Magnetic resonance imaging (MRI) typically showed intramedullary lesions, and most dogs responded positively to immunosuppressive treatments, but there was a higher duration of clinical signs compared to dogs with intervertebral disc herniation.
Brain magnetic resonance imaging of patients with spinal muscular atrophy type 2 and 3.
Neuroimage Clin
November 2024
UMC Utrecht Brain Center, Department of Neurology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:
Background And Objective: Proximal spinal muscular atrophy (SMA) is caused by deficiency of the ubiquitously expressed survival motor neuron protein. Although primarily a hereditary lower motor neuron disease, it is probably also characterized by abnormalities in other organs. Brain abnormalities and cognitive impairment have been reported in severe SMA.
View Article and Find Full Text PDFMeningeal Dissemination and Drop Metastasis From Glioma Presenting With Non-Epileptic Myoclonus and Minipolymyoclonus.
Neurohospitalist
October 2024
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
We describe the case of a 36-year-old woman with a past medical history of low grade right frontal lobe glioma and focal epilepsy presenting with subacute, progressive, multifocal myoclonus and neck and back pain. Unlike her typical seizures, the myoclonus exhibited a distinct semiology, involving both positive and negative muscle jerks affecting multiple limb muscles while sparing the face. In addition, neurological examination revealed low-amplitude, arrhythmic movements of the hands and fingers, resembling minipolymyoclonus.
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