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Development and characterisation of a novel complex triple cell culture model of the human alveolar epithelial barrier.
In Vitro Model
June 2024
In Vitro Toxicology Group, Faculty of Medicine, Health and Life Sciences, Swansea University Medical School, Swansea University, Sketty, Wales SA2 8PP UK.
Unlabelled: Owing to increased pressure from ethical groups and the public to avoid unnecessary animal testing, the need for new, responsive and biologically relevant in vitro models has surged. Models of the human alveolar epithelium are of particular interest since thorough investigations into air pollution and the effects of inhaled nanoparticles and e-cigarettes are needed. The lung is a crucial organ of interest due to potential exposures to endogenous material during occupational and ambient settings.
View Article and Find Full Text PDFThe gastrointestinal epithelium serves as a critical barrier separating intestinal lumen contents from the underlying tissue environment. Structure and function of the apical junctional complex (AJC), comprising tight and adherens junctions, are essential for establishing and maintaining a polarized and functional epithelial barrier. In this study, we investigated mechanisms by which an apical polarity protein Crumbs homolog 3 (CRB3) regulates AJC assembly and barrier function in primary murine intestinal epithelial cells.
View Article and Find Full Text PDFCone-beam Computed Tomography Evaluation Timings of Closure of Open Apex by Using Deciduous Tooth Pulp Autotransplantation for the Regenerative Endodontic Treatment of Permanent Teeth with Pulp Necrosis.
Contemp Clin Dent
December 2024
Department of Pediatric and Preventive Dentistry, GDC, Dibrugarh, Assam, India.
Regenerative endodontic therapy (RET) of young permanent teeth with necrotic pulps and apical periodontitis in young people, deciduous tooth pulp may be utilized as a natural, biologic scaffold. Recent developments in stem cell biology and material sciences are beneficial for new treatment methods. Previously traumatized and necrotic young permanent tooth was treated with RET protocol.
View Article and Find Full Text PDFPlastic nanoparticle toxicity is accentuated in the immune-competent inflamed intestinal tri-culture cell model.
Nanotoxicology
January 2025
Department of Pharmaceutical Sciences & Administration, School of Pharmacy, Westbrook College of Health Professions, University of New England, Portland, Maine, USA.
Important cell-based models of intestinal inflammation have been advanced in hopes of predicting the impact of nanoparticles on disease. We sought to determine whether a high level and extended exposure of nanoplastic might result in the added intestinal inflammation caused by nanoplastic reported in a mouse model of irritable bowel disease. The cell models consist of a Transwell©-type insert with a filter membrane upon which lies a biculture monolayer of Caco-2 and HT29-MTX-E12 made up the barrier cells (apical compartment).
View Article and Find Full Text PDFIron transfer across a functional syncytialized trophoblast monolayer.
Placenta
November 2024
Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland. Electronic address:
Studying iron transfer across trophoblast monolayers is crucial given the significance of iron in maintaining a healthy pregnancy and supporting fetal growth and development. To get insights into the complex mechanism of transplacental iron transfer, we developed a standardized Transwell®-based monolayer model using BeWo (clone b30) cells. Our proposed method is divided into two parts: 1.
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