AI Article Synopsis
- Zta is a protein produced by the BZLF1 gene of the Epstein-Barr virus (EBV) that plays a key role in reactivating the virus from its dormant state.
- Zta belongs to the bZIP family of transcription factors, which are characterized by specific cysteine residues that are important for their function.
- Research shows that the cysteine at position 189 (C189) is essential for EBV reactivation by affecting its ability to bind to a specific DNA site and also influence the cell cycle, while the cysteine at position 222 (C222) is not necessary for these functions.
Article Abstract
Zta, the product of the BZLF1 gene carried by Epstein-Barr virus (EBV), is crucial for reactivation of EBV from latency. Zta is a member of the bZIP family of transcription factors, and in common with many of these, Zta possesses a conserved cysteine residue in its basic region (C189) and a further cysteine residue in its ZIP region (C222). We demonstrate that C189 is required to reactivate EBV from latency but C222 is not and that this single amino acid affects two independent functions of Zta, (i) binding to a Zta-responsive site and (ii) manipulating the cell cycle.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262594 | PMC |
| http://dx.doi.org/10.1128/JVI.79.21.13822-13828.2005 | DOI Listing |
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