We report the characterization of a near full-length sequence of a South American HIV-1 BC intersubtype recombinant, ARE195FL. This isolate contains a C(gag/pol) B(vpr/vpu/gp160(env)) C(gp41(env)/nef) mosaic structure differing from any BC full-length sequence described to date, and is the first full-length sequence obtained from a South American BC strain. Neighbor-joining analysis revealed that subtype C genomic segments of ARE195FL clustered with the South American group of subtype C strains, suggesting a local emergence of the BC recombinant. Despite having dissimilar genomic structures, ARE195FL shares a common recombination breakpoint in vif, which is a "hot spot" for recombinatory events, with the Chinese BC recombinant prototype CRF07_BC. Further full-length sequence analysis of South American HIV-1 C and BC strains is necessary to determine the relevance and spread of emerging HIV-1 BC recombinants in Latin America.
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| http://dx.doi.org/10.1089/aid.2005.21.894 | DOI Listing |
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