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Possible involvement of apoptosis in the antipsychotics side effects: A mini-review.
Clin Exp Pharmacol Physiol
August 2022
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Antipsychotics are used in the treatment of schizophrenia and other psychiatric disorders. Generally, they are divided into typical and atypical ones, according to the fact that atypical antipsychotics induce fewer side effects and are more effective in terms of social and cognitive improvements. Their pharmacological effects are mediated via broad range of receptors that consequently influence different cellular signalling pathways.
View Article and Find Full Text PDFThe Neck of Femur Fracture in an Elderly Patient with Schizophrenia and Parkinsonism Managed with Dual Mobility Total Hip Replacement- A Rare Case Report.
J Orthop Case Rep
June 2021
Department of Orthopaedics, Grant Government Medical College, Mumbai, Maharashtra, India.
Introduction: Neck of femur fractures is the most common fractures in elderly people as they present with osteoporosis. There is a higher chance of proximal femur fracture in a schizophrenic patient as there is a loss of bone mineral density due to a drug-induced increase in the level of prolactin and immobility. Patients with Parkinson's disease were at higher risk for the development of hip fractures due to gait disturbances and instability.
View Article and Find Full Text PDFA Rare Presentation: Cauda Equina Compression Secondary to an L1 Burst Fracture in Osteoporosis.
Cureus
January 2022
Department of Orthopaedic Surgery, Sengkang General Hospital, Singapore, SGP.
Cauda equina syndrome (CES) rarely occurs in upper lumbar spinal pathologies above L2. Osteoporosis is a consideration in determining the operative approach. We report a case of CES as a result of an L1 burst fracture in an osteoporotic lady with schizophrenia.
View Article and Find Full Text PDFGaps or links between hormonal therapy and schizophrenia? (Review).
Exp Ther Med
October 2020
Department of Psychiatry, 'Prof. Dr. Alexandru Obregia' Clinical Psychiatry Hospital, 041914 Bucharest, Romania.
Schizophrenia is considered the most severe and debilitating psychiatric disorder. During the 80's, first reports on abnormalities of the schizophrenic brain which could be objectively observed on MRI, CT scans and other imagistic techniques were published. This showed that schizophrenia is a disorder that goes beyond the functional aspect of the symptomatology.
View Article and Find Full Text PDF[The association of schizophrenia with chronic non transmissible diseases].
Rev Med Chil
August 2017
Departamento de Psiquiatría, Sede Sur., Escuela de Medicina. Facultad de Medicina, Universidad de Chile, Santiago, Chile.
The life expectancy of patients with schizophrenia (SCH) is 11 to 20 years less than the general population. There is an association between SCH and various diseases and chronic conditions, highlighting the cardio-metabolic diseases. This association has been attributed to the use of antipsychotics, however, evidence has also shown intrinsic susceptibility of schizophrenic patients the development of chronic conditions.
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