Background: The association between elevated levels of triglycerides and insulin may be weaker in African American women (AAW) than in women of other groups, leading to under diagnosis of the metabolic syndrome (MetS) in AAW when using the National Cholesterol Education Program (NCEP) criteria, as those criteria do not include a marker of insulin resistance, using elevated triglycerides to provide an indirect indication of insulin resistance.

Objectives: To determine the degree of agreement between two definitions for the MetS, that described by the NCEP and the NCEP criteria with the addition of a marker of insulin resistance in a sample of AAW.

Method: This non experimental pilot study took place in the General Clinical Research Center of a major medical center. Thirty-three AAW 19-45 years of age were screened using the NCEP criteria for MetS, additional markers of insulin resistance, and a 2-hour Oral Glucose Tolerance Test.

Findings: Six (18%) women were classified as having the MetS using the NCEP criteria. When one of three markers for insulin resistance (hyperinsulinemia, acanthosis nigricans, or Homeostatic Model Assessment Insulin Resistance) was added to the criteria, 15 (45.5%) to 19 (59.5%) of the women were then identified as having MetS.

Discussion: As identified in the literature, the prevalence of cardiovascular disease risk in AAW may be underestimated based on the sole use of the NCEP criteria. Further, because there is some evidence that insulin resistance develops before many other indicators, the addition of a marker of insulin resistance may assist in earlier identification of AAW at high risk for cardiovascular disease.

Download full-text PDF

Source
http://dx.doi.org/10.1097/00006199-200509000-00008DOI Listing

Publication Analysis

Top Keywords

insulin resistance
28
ncep criteria
20
marker insulin
12
insulin
9
african american
8
american women
8
metabolic syndrome
8
national cholesterol
8
cholesterol education
8
education program
8

Similar Publications

Arsenic exposure can induce liver insulin resistance (IR) and diabetes (DM), but the underlying mechanisms are not yet clear. Circular RNAs (circRNAs) are involved in the regulation of the onset of diabetes, especially in the progression of IR. This study aimed to investigate the role of circRNAs in arsenic-induced hepatic IR and its underlying mechanism.

View Article and Find Full Text PDF

: The prevalence of metabolic syndrome in children has been increasing, raising concerns about early detection and clinical management. Adipokines, which are secreted by adipose tissue, play a critical role in metabolic regulation and inflammation, while gamma-glutamyl transferase (GGT), as a liver enzyme, is linked to oxidative stress and metabolic disorders. The objective was to examine the association of circulating adipokines and GGT with metabolic syndrome risk in school-aged children from Northeast Mexico.

View Article and Find Full Text PDF

Background: Anabolic resistance accelerates muscle loss in aging and obesity, thus predisposing to sarcopenic obesity.

Methods: In this retrospective analysis of a randomized clinical trial, we examined baseline predictors of the adaptive response to three months of home-based resistance exercise, daily physical activity, and protein-based, multi-ingredient supplementation (MIS) in a cohort of free-living, older males ( = 32).

Results: Multiple linear regression analyses revealed that obesity and a Global Risk Index for metabolic syndrome (MetS) were the strongest predictors of Δ% gains in lean mass (TLM and ASM), LM/body fat ratios (TLM/%BF, ASM/FM, and ASM/%BF), and allometric LM (ASMI, TLM/BW, TLM/BMI, ASM/BW), with moderately strong, negative correlations to the adaptive response to polytherapy r = -0.

View Article and Find Full Text PDF

: It is unknown whether the negative health effects associated with ultra-processed foods (UPFs) are due to their nutritional composition or to the extent of food processing itself. We evaluated the impact of a test meal composed only of UPF, according to the NOVA classification, compared to a similar meal without UPF in adults with obesity. : This is a parallel, randomized trial.

View Article and Find Full Text PDF

: The ketogenic diet (KD) is a dietary model that can impact metabolic health and microbiota and has been widely discussed in recent years. This study aimed to evaluate the effects of a 6-week KD on biochemical parameters, gut microbiota, and fecal short-chain fatty acids (SCFAs) in women with overweight/obesity. : Overall, 15 women aged 26-46 years were included in this study.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!