Aim: It is aim of this paper to investigate the outcome of direct-placement restorations provided within the General Dental Services in England and Wales, in relation to the factors related to time and place of restoration placement.
Methods: A modified version of Kaplan-Meier statistical methodology was used to plot survival curves for restorations placed at different times and places, within the population of patients for whom data were available.
Results: The results indicated that overall, restoration survival time to re-intervention has declined over the last decade, but that most of the decline can be accounted for by the change in the relative numbers of amalgam and other direct restorations. Restoration survival to re-intervention is independent of whether the water is fluoridated in the area of the dentist's surgery address. Variation with region is not great, but restorations placed in Wales survived to re-intervention significantly longer than those in England (P<0.0001).
Conclusions: Overall, there was some evidence of a reduction in survival times with time. Restorations placed in Wales survived longer to re-intervention than restorations placed in England. Restoration survival was not dependent on whether the dentist who placed the restoration practised in an area in which the water was fluoridated. Performance of amalgam restorations was not found to have altered significantly with time, but performance of composite and glass ionomer deteriorated with time.
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http://dx.doi.org/10.1016/j.jdent.2005.03.010 | DOI Listing |
Front Biosci (Landmark Ed)
January 2025
Department of Cardiology, Affiliated Hospital of Jiangnan University, 214122 Wuxi, Jiangsu, China.
Background: Myocardial ischemia-reperfusion (I/R) injury refers to cell damage that occurs as a consequence of the restoration of blood circulation following reperfusion therapy for cardiovascular diseases, and it is a primary cause of myocardial infarction. The search for nove therapeutic targets in the context of I/R injury is currently a highly active area of research. p70 ribosomal S6 kinase (S6K1) plays an important role in I/R induced necrosis, although the specific mechanisms remain unclear.
View Article and Find Full Text PDFMicroorganisms
January 2025
Intensive Care Unit, Sismanogleio General Hospital, 37 Sismanogleiou Str., 15126 Marousi, Greece.
Metabolic disorders, including type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome, are systemic conditions that profoundly impact the skin microbiota, a dynamic community of bacteria, fungi, viruses, and mites essential for cutaneous health. Dysbiosis caused by metabolic dysfunction contributes to skin barrier disruption, immune dysregulation, and increased susceptibility to inflammatory skin diseases, including psoriasis, atopic dermatitis, and acne. For instance, hyperglycemia in T2DM leads to the formation of advanced glycation end products (AGEs), which bind to the receptor for AGEs (RAGE) on keratinocytes and immune cells, promoting oxidative stress and inflammation while facilitating Staphylococcus aureus colonization in atopic dermatitis.
View Article and Find Full Text PDFBiomolecules
January 2025
National Center for Global Health, Italian Institute of Health, 00161 Rome, Italy.
In chronic lymphocytic leukemia (CLL), natural killer (NK) cells show a dysfunctional phenotype that correlates with disease progression. Our aim was to restore NK cell functionality in CLL through a specifically targeted IL15-stimulating activity; IL15 targeting could, in fact, potentiate the activity of NK cells and reduce off-target effects. We designed and developed a cis-acting immunocytokine composed of an anti-CD56 single-chain Fragment variable (scFv) and IL15, labeled scFvB1IL15.
View Article and Find Full Text PDFHealthcare (Basel)
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
This study aimed to analyze the research progress on the use of a multifocal lens for myopic control throughout the 21st century, utilizing bibliometric analysis. Publications related to multifocal lenses from 2001 to 2024 were searched on the Web of Science core collection (WoSCC) database. VOSviewer (Version 1.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Center of Digital Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Background: Establishing accurate, reliable, and convenient methods for enamel segmentation and analysis is crucial for effectively planning endodontic, orthodontic, and restorative treatments, as well as exploring the evolutionary patterns of mammals. However, no mature, non-destructive method currently exists in clinical dentistry to quickly, accurately, and comprehensively assess the integrity and thickness of enamel chair-side. This study aims to develop a deep learning work, 2.
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