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Prediction of antimicrobial susceptibility of pneumococci based on whole-genome sequencing data: a direct comparison of two genomic tools to conventional antimicrobial susceptibility testing.
J Clin Microbiol
December 2024
Laboratory of Clinical Microbiology, KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Flanders, Belgium.
Determination of antimicrobial resistance (AMR) in pneumococcal isolates is important for surveillance purposes and in a clinical context. Antimicrobial susceptibility testing (AST) of pneumococci is complicated by the need for exact minimal inhibitory concentrations (MICs) of beta-lactam antibiotics. Two next-generation sequencing (NGS) analysis tools have implemented the prediction of AMR in their analysis workflow, including the prediction of MICs: Pathogenwatch (https://pathogen.
View Article and Find Full Text PDFChanges in population genetic structure of serotype 19A Streptococcus pneumoniae after universal childhood use of the 10-valent pneumococcal conjugate vaccine in Brazil.
Vaccine
December 2024
Instituto Biomédico, Universidade Federal Fluminense, Alameda Barros Terra, s/n, São Domingos, Niterói, RJ 24020-150, Brazil. Electronic address:
Article Synopsis
- The introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) in Brazil has significantly decreased the prevalence of vaccine serotype-related invasive pneumococcal disease (IPD) in children, but non-vaccine serotypes, particularly 19A, have become more prominent.
- The study analyzed 32 serotype 19A isolates from a variety of patients, finding that the majority of these isolates came from children and displayed high levels of non-susceptibility to commonly used antibiotics.
- A significant number of the isolates were multidrug resistant, with a notable shift in genetic lineages, indicating evolving resistance patterns following the introduction of PCV10.
Serotype 3 Streptococcus pneumoniae Escapes the Immune Responses Induced by PCV13 in Mice With High Susceptibility to Infection.
Immun Inflamm Dis
December 2024
Bacteriology Laboratory, Instituto Butantan, São Paulo, Brazil.
Background: Streptococcus pneumoniae (pneumococcus) is a common cause of respiratory and invasive infections in humans. PCV13, a pneumococcal conjugate vaccine used globally, is highly effective against diseases caused by pneumococcal serotypes included in its formulation. However, one of them, the serotype 3 (ST3) is still being relatively commonly isolated from patients, suggesting an escape from vaccine-induced immunity.
View Article and Find Full Text PDFA genome-based survey of invasive pneumococci in Norway over four decades reveals lineage-specific responses to vaccination.
Genome Med
October 2024
Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway.
Article Synopsis
- Streptococcus pneumoniae is a significant global health threat, but pneumococcal conjugate vaccines (PCVs) have notably decreased cases of targeted serotypes.
- Research conducted over 41 years in Norway utilized whole-genome sequencing to analyze historical and contemporary isolates of S. pneumoniae, revealing shifts in serotype populations.
- Findings indicate that while PCVs have decreased invasive disease, they also led to some serotype switching to non-vaccine types, indicating a dynamic evolutionary response in the bacterial population.
To describe the profile of , identify research gaps, and provide in-depth insights into various aspects related to the pathogen. Google Scholar, PubMed, and ScienceDirect were searched for all studies on the pneumococcus in Ghana that reported on specimen collected, population and sample size, carriage prevalence, incidence of pneumococcal diseases, age of the study population, types of test performed, serotypes identified, antimicrobial susceptibilities, or molecular analysis on the pneumococci for data extraction. Overall, a total of 7954 results were obtained from the three-database search, and of this, 24 articles were selected after screening.
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