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Randomized Controlled Trial of Preconception Interventions in Infertile Women With Polycystic Ovary Syndrome.
J Clin Endocrinol Metab
November 2015
Departments of Obstetrics and Gynecology (R.S.L., W.C.D., C.L.G., S.J.E.) and Public Health Sciences (R.S.L., A.R.K., C.M.S.), Penn State College of Medicine, Hershey, PA, Departments of Nutritional Sciences (P.M.K., J.F.) and Kinesiology (N.I.W.), Penn State College of Health and Human Development, University Park, Pennsylvania 16802; and Departments of Psychiatry (D.B.S., K.C.A.), Surgery (D.B.S.), and Obstetrics and Gynecology (A.D., C.C.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Context: Lifestyle modification is recommended in women with polycystic ovary syndrome (PCOS) prior to conception but there are few randomized trials to support its implementation or benefit.
Objective: This study aimed to determine the relative efficacy of preconception intervention on reproductive and metabolic abnormalities in overweight/obese women with PCOS.
Design, Setting, And Participants: This was a randomized controlled trial of preconception and infertility treatment at Academic Health Centers in women with infertility due to PCOS, age 18-40 y and body mass index 27-42 kg/m(2).
A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos.
Microsc Res Tech
August 2015
Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Arcadia, South Africa.
Exposure to drugs during pregnancy is a major concern, as some teratogenic compounds can influence normal foetal development. Although the use of drugs during pregnancy should generally be avoided, exposure of the developing foetus to teratogens may occur unknowingly since these compounds may be hidden in products that are being marketed as "all natural." The aim of the current study was to investigate the possible teratogenic and cellular effects of sibutramine-a serotonin-norepinephrine reuptake inhibitor used in the treatment of obesity-on the heart and liver tissue of chick embryos.
View Article and Find Full Text PDFAntiobesity drugs in early pregnancy and congenital malformations in the offspring.
Obes Res Clin Pract
October 2015
Tornblad Institute, Lund University, Biskopsgatan 7, SE-223 62 Lund, Sweden. Electronic address:
Little information exists on the possible teratogenic effect of modern antiobesity drugs. The present study refers to orlistat, sibutramine, and rimonabant. Data in the Swedish Medical Birth Register were utilised.
View Article and Find Full Text PDFAppetite suppressants in pregnancy.
Neuro Endocrinol Lett
April 2013
Department of Histology and Embryology, Charles University, Prague, Czech Republic.
Objectives: Both, obesity as well as anorexia may be associated with infertility and other complications of pregnancy. Weight loss during pregnancy is therefore considered a risk factor. Weight loss and appetite suppressant are contraindicated during pregnancy, but the unintended exposure is probably not associated with higher risk.
View Article and Find Full Text PDFA case of sibutramine-induced hyperprolactinemia.
Neuro Endocrinol Lett
March 2012
Neuroendocrinology Center of Santa Casa de Porto Alegre, UFCSPA, Brazil.
Introduction: Several drugs may cause hyperprolactinemia, especially antipsychotic drugs and prokynetic drugs. Serum prolactin concentrations increase within hours after acute administration of these drugs and return to normal within two to four days after cessation of chronic therapy. So far, sibutramine, a sympathomimetic drug used in the management of obesity, was not described to be associated with altered prolactin levels.
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