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Mechanism of - for treatment of primary liver cancer: analysis with network pharmacology, molecular docking and validation.
Nan Fang Yi Ke Da Xue Xue Bao
January 2025
Department of Infection, Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230038, China.
Objectives: To investigate the active ingredients in Hedyotis diffusa-Scutellaria barbata D. Don and the main biological processes and signaling pathways mediating their inhibitory effect on primary hepatocellular carcinoma (HCC).
Methods: The core intersecting genes of HCC and the two drugs were screened from TCMSP, Uniport, Genecards, and String databases using Cytoscape software, and GO and KEGG enrichment analyses of the intersecting genes were conducted.
Exploration of the molecular mechanism of Wufu Yin in the treatment of knee osteoarthritis based on network pharmacology and experimental validation.
Medicine (Baltimore)
November 2024
Department of Orthopedics, Shaoxing Traditional Chinese Medicine Hospital, Shaoxing, Zhejiang, China.
Wufu Yin (WFY) exhibits significant clinical effectiveness in knee osteoarthritis (KOA) treatment, yet its therapeutic mechanisms are still unclear. This study aimed to explore the active ingredients and potential mechanism of WFY in the treatment of KOA. The network pharmacology-based approach was adopted to investigate the underlying mechanism of WFY in treating KOA.
View Article and Find Full Text PDFMolecular docking and network pharmacology research on the Danggui Sini Decoction's mechanism of action for treating erectile dysfunction.
Medicine (Baltimore)
November 2024
College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Utilizing network pharmacology and molecular docking, we evaluated the possible pharmacological mechanism of Danggui Sini Decoction (DGSND) for treating erectile dysfunction (ED). DGSND's chemical components and targets were found utilizing the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Disease-related genes associated with ED were identified through GeneCards, OMIM, TTD, DrugBank, and DisGeNET databases.
View Article and Find Full Text PDF[Effects of different drying methods on content of main chemical compounds in Callicarpae Nudiflorae Folium].
Zhongguo Zhong Yao Za Zhi
December 2024
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
This study aims to identify the main chemical compounds, investigate the effects of different drying methods on the quality, and determine the appropriate drying method of Callicarpae Nudiflorae Folium. UPLC-UV-Q-TOF-MS was employed to characterize and identify 35 main compounds, including phenylethanoid glycosides, flavonoids, and iridoids in Callicarpae Nudiflorae Folium. A method for the simultaneous determination of 8 compounds with strong UV absorption and high content was established to evaluate the quality of Callicarpae Nudiflorae Folium dried by different methods.
View Article and Find Full Text PDF[Selection and reflection on ecological fine manufacturing model of traditional Chinese medicine under "dual carbon" goals].
Zhongguo Zhong Yao Za Zhi
December 2024
Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China National Key Laboratory of Classic Formula Modern Chinese Medicine Creation Nanchang 330004, China.
At present, China's traditional Chinese medicine(TCM) industry is developing rapidly with the support of modern science and technology. While promoting economic development and improving national health, it has brought multiple environmental problems. Under the "dual carbon" goals, the ecological fine manufacturing of TCM may become one of the breakthroughs for the TCM industry to practice low-carbon economy.
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