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Allergen Immunotherapy in Autoimmune Terrain: A Case Study.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Endocrinology, Joshi Clinic, Mumbai, India.
Allergen immunotherapy (AIT), or specific immunotherapy (SIT), is an effective treatment for inducing immune tolerance to specific allergens. It is widely used for allergic rhinitis, conjunctivitis, asthma, and Hymenoptera venom allergies, with recent applications to food allergies and atopic dermatitis. Despite its benefits, the use of SIT in patients with autoimmune diseases is controversial due to concerns about its potential to induce or exacerbate autoimmune conditions.
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- Asthma is a complex inflammatory disease that can be influenced by various underlying mechanisms, and this study focused on patients with both asthma and primary antibody immunodeficiency (PAD).
- Out of 33 patients studied, those with low T2 inflammatory markers showed a significant increase in blood eosinophils after receiving immunoglobulin therapy (IVIg), which is associated with better asthma management.
- The results indicate that IVIg therapy leads to a notable decrease in respiratory infections and asthma exacerbations in patients with asthma and PAD, suggesting it might help change the way asthma presents in these patients.
Epithelial FETUB-mediated the inhibition of NEP activity aggravates asthma.
Int Immunopharmacol
March 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing 210029, China. Electronic address:
Background: Neuropeptide accumulation exacerbates asthma, with reduced neprilysin (NEP) activity implicated. However, this regulatory mechanism remains unexplored.
Objective: To identify and characterize epithelial-derived modulators of NEP activity and their role in asthma pathogenesis.
Heated High Flow Nasal Cannula and Bilevel Positive Airway Pressure in Pediatric Asthma Exacerbations.
J Asthma
March 2025
Department of Pediatrics, University of Rochester, Rochester, NY, U.S.A.
Objective: Heated High Flow Nasal Cannula (HHFNC) and Bilevel Positive Airway Pressure (BPAP) are non-invasive respiratory support modalities used in pediatric asthma exacerbations. We aim to examine differences in characteristics and outcomes for patients admitted to the Pediatric Intensive Care Unit (PICU) on standard therapy (ST) alone (continuous albuterol and systemic corticosteroids), ST plus HHFNC, and ST plus BPAP.
Methods: This is a retrospective and prospective observational cohort study.
Safety and effectiveness of mepolizumab in adult patients with severe asthma with an eosinophilic phenotype from India: a Phase IV, open-label, single-arm, 24-week study (PRISM).
J Asthma
March 2025
Medical Affairs, GSK, Mumbai, India.
ObjectiveExisting mepolizumab trials have excluded patients with severe asthma with an eosinophilic phenotype (SAEP) from India. This study (NCT04276233) investigated the safety and effectiveness of mepolizumab in Indian adults with SAEP.MethodsMulti-centre, open-label, single-arm, interventional study; patients received 100 mg mepolizumab subcutaneously every four weeks for 24 weeks.
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