A novel series of potent inhibitors of Ras farnesyl transferase possessing a 1,2,4-triazole pharmacophore is described. These inhibitors were discovered from a parallel synthesis effort and were subsequently optimized to in vitro IC(50) value of less than 1nM.
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| http://dx.doi.org/10.1016/j.bmcl.2005.09.007 | DOI Listing |
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