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Genome-wide association mapping of biochemical traits and its correlation with MYMIV resistance in mungbean (Vigna radiata L. Wilczek).
Sci Rep
December 2024
Division of Genetics, Indian Agricultural Research Institute, New Delhi, 110012, India.
The mungbean yellow mosaic India virus (MYMIV, Begomovirus vignaradiataindiaense) causes Yellow Mosaic Disease (YMD) in mungbean (Vigna radiata L.). The biochemical assays including total phenol content (TPC), total flavonoid content (TFC), ascorbic acid (AA), DPPH (2,2-diphenyl-1-picrylhydrazyl), and FRAP (Ferric Reducing Antioxidant Power) were used to study the mungbean plants defense response to MYMIV infection.
View Article and Find Full Text PDFSOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis.
Sci Rep
December 2024
Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ, USA.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of Cytokine Signaling) domain is a 40 amino acid conserved domain known to form a functional ubiquitin ligase complex targeting the Von Hippel Lindau (VHL) protein for proteasomal degradation. Here we show that the SOCS conserved domain operates as a molecular tool, to disrupt collagen and fibronectin fibrils in the ECM associated with fibrotic lung myofibroblasts.
View Article and Find Full Text PDFDevelopment of a prognostic gene signature and exploration of P4HA1 in the modulation of cuproptosis in colorectal cancer.
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December 2024
School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People's Republic of China.
Cuproptosis, a newly identified form of cell death, has drawn increasing attention for its association with various cancers, though its specific role in colorectal cancer (CRC) remains unclear. In this study, transcriptomic and clinical data from CRC patients available in the TCGA database were analyzed to investigate the impact of cuproptosis. Differentially expressed genes linked to cuproptosis were identified using Weighted Gene Co-Expression Network Analysis (WGCNA).
View Article and Find Full Text PDFUltrafast silicon photonic reservoir computing engine delivering over 200 TOPS.
Nat Commun
December 2024
Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Reservoir computing (RC) is a powerful machine learning algorithm for information processing. Despite numerous optical implementations, its speed and scalability remain limited by the need to establish recurrent connections and achieve efficient optical nonlinearities. This work proposes a streamlined photonic RC design based on a new paradigm, called next-generation RC, which overcomes these limitations.
View Article and Find Full Text PDFA parallel CNN architecture for sport activity recognition based on minimal movement data.
Sci Rep
December 2024
Henan College of Transportation, Zhengzhou, 450000, Henan, China.
Novel Human Activity Recognition (HAR) methodologies, which are built upon learning algorithms and employ ubiquitous sensors, have achieved remarkable precision in the identification of sports activities. Such progress benefits all age groups of humanity, and in the future, AI will be used to address difficult problems in scientific research. A novel approach is introduced in this article to utilize motion sensor data in order to categorize and distinguish various categories of sports activities.
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