AI Article Synopsis
- T lymphocytes with suppressor function, known as Tregs, help maintain immune balance in the body.
- Different types of Tregs have been found in CD4 and CD8 T cell groups, suggesting they play a role in reducing autoimmune responses and improving outcomes in transplantation and cancer.
- This review highlights the recent findings about CD8 Tregs, covering their specific targets, characteristics, how they interact with other immune cells, and their activation process.
Article Abstract
T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit a pathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!