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Preferences for thromboprophylaxis in the intensive care unit: An international survey.
Acta Anaesthesiol Scand
April 2025
Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Background: Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recommendations.
Objective: This survey aims to assess current thromboprophylaxis preferences and willingness to participate in future randomized clinical trials (RCTs) on this topic.
Venous thrombosis related to duplicated inferior vena cava: A case report and systematic review.
Medicine (Baltimore)
February 2025
Department of Nursing, MacKay Junior College of Medicine Nursing and Management, Taipei Taiwan.
Rationale: Swollen legs are commonly observed in clinical practice, and deep vein thrombosis (DVT) is 1 of the causes. Duplicated IVC (DIVC) is a relatively rare anomaly that results in DVT.
Patient Concerns: A 52-year-old male patient presented to the emergency department because of right leg swelling, pain, and redness for 3 days.
Exploration of biomaterial-tissue integration in heterogeneous microporous annealed particle scaffolds in subcutaneous implants over 12 months.
Acta Biomater
February 2025
Department of Biomedical Engineering and the Department of Chemical Engineering, University of Virginia, 415 Lane Road, Rm 1111, Charlottesville, VA 22903. Electronic address:
Microporous annealed particle (MAP) scaffolds are comprised of hydrogel microparticles with inter- and intra-particle cross-links that provide structure and cell-scale porosity, making them an increasingly attractive option for injectable tissue augmentation. Many current injectable biomaterials create a substantial foreign body response (FBR), while MAP scaffolds mitigate this response and have the potential to facilitate the formation of new tissue, though this de novo tissue formation is poorly understood. Here, we leverage a subcutaneous implant model to explore the maturation of MAP implants with and without heparin microislands (µislands) over one year to identify the effect of bioactive particles on scaffold maturation.
View Article and Find Full Text PDFCustomized Heparinized Alginate and Collagen Hydrogels for Tunable, Local Delivery of Angiogenic Proteins.
ACS Biomater Sci Eng
March 2025
School of Engineering, Institute for Biology, Engineering, and Medicine, Brown University, Providence, Rhode Island 02912, United States.
Therapeutic protein delivery has ushered in a promising new generation of disease treatment, garnering more recognition for its clinical potential than ever. However, proteins' limited stability, extremely short average half-lives, and evidenced toxicity following systemic delivery continue to undercut their efficacy. Biomaterial-based protein delivery, however, demonstrates the potential to overcome these obstacles.
View Article and Find Full Text PDFAnti-xa guided enoxaparin thromboprophylaxis is associated with less thromboembolism than fixed dose dalteparin in trauma patients admitted to intensive care.
Eur J Trauma Emerg Surg
February 2025
Department of Surgery, Trauma Surgery, Hamad Medical Corporation, Doha, Qatar.
Background: Venous Thromboembolism (VTE) is a common, preventable complication in trauma. Low-molecular-weight heparin (LMWH) is recommended for VTE prophylaxis (VTEp). We investigated whether switching from fixed-dose dalteparin to anti-Xa-guided enoxaparin prophylaxis reduces VTE without increasing the risk of bleeding among hospitalized trauma patients.
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