The optimal anticoagulation following Fontan operation and its modifications remain controversial and it is even less well defined as regards patients with inherited thrombophilia. We present a case of a child with bidirectional Glenn anastomosis for double inlet left ventricle that suffered a stroke despite aspirin prophylaxis; the patient was combined homozygous for prothrombin G20210A mutation and for methylenetetrahydrofolate reductase C677T mutation as well. The family history was positive for fetal loss and premature cardiovascular disease. Large-scale studies are needed to evaluate whether carriers of thrombophilia mutations need more intense thromboprophylaxis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2005.07.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extracorporeal Cardiopulmonary Resuscitation Outcomes in Pre-Glenn Single Ventricle Infants: Analysis of A Ten-Year Dataset.
Resuscitation
January 2025
Department of Surgery, Division of Congenital Cardiac Surgery, University of Washington, Seattle Children's Hospital, Seattle, WA.
Background: While several studies have reported on outcomes of extracorporeal membrane oxygenation (ECMO) in patients with single ventricle physiology, few studies have described outcomes of extracorporeal cardiopulmonary resuscitation (ECPR) in this unique population. The objective of this study was to determine survival and risk factors for mortality after ECPR in single ventricle patients prior to superior cavopulmonary anastomosis, using a large sample from the Extracorporeal Life Support Organization (ELSO) Registry.
Methods: We included single ventricle patients who underwent ECPR for in-hospital cardiac arrest (IHCA) between January 2012 and December 2021.
Reimplantation of Thymus at the First Superior Cavo-Pulmonary Anastomosis and Its Outcome.
Cureus
December 2024
Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, IND.
During bidirectional cavo-pulmonary anastomosis (bidirectional Glenn; BDG), the thymic tissue is often excised to facilitate the exposure of the superior vena cava and its junction with the innominate vein. Subsequently, it is discarded. Since the last two decades, the lead author (ST) has pursued anchoring the excised thymus in its position by suturing it to the opposite unexcised thymic lobe.
View Article and Find Full Text PDFCatheter-Based Fontan Completion Without Prior Surgical Preparation: Is This the Way Forward?
JACC Case Rep
November 2024
Department of Cardiothoracic Surgery, Apollo Children's Hospital, Chennai, Tamilnadu, India.
We report 3 cases of transcatheter Fontan completion in conventional Glenn anastomosis patients without surgical preparation by creating a tunnel between the pulmonary artery and right atrium. Cavocaval anastomosis is established by placing a covered stent graft within the scaffold created with the uncovered stents at the pulmonary artery-right atrium and inferior vena cava-right atrium junction.
View Article and Find Full Text PDFGlenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations.
Physiol Rep
November 2024
Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Children's Wisconsin, Herma Heart Institute, Milwaukee, Wisconsin, USA.
Pulmonary arteriovenous malformations (PAVMs) universally develop in patients with single ventricle congenital heart disease. Single ventricle PAVMs have been recognized for over 50 years but remain poorly understood. To improve our understanding, we developed a surgical rat model of Glenn circulation and characterized PAVM physiology over multiple time points.
View Article and Find Full Text PDFTwo hundred and twenty-nine cases of bidirectional cavopulmonary anastomosis with and without antegrade pulmonary blood flow, a single-center experience.
Cardiol Young
October 2024
Department of Cardiology, Ukrainian Children's Cardiac Center, Kyiv, Ukraine.
Bidirectional cavopulmonary anastomosis is palliative surgical procedure for stepwise adaptation of the ventricle by time-phased relief of blood volume from the single functional ventricle. There still exists a controversial question regarding maintaining additional antegrade pulmonary blood flow. We retrospectively reviewed the surgical cases of 261 patients who underwent bidirectional cavopulmonary anastomosis in our institution from 2012 to 2022 with special regard to antegrade pulmonary blood flow as our preferred strategy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!