AI Article Synopsis
- A palladium-catalyzed reaction can couple allylic acetates with aryl groups, leading to products similar to those obtained through Heck coupling.
- The best results were achieved using ligand-free palladium on carbon combined with tetrabutylammonium chloride, a trialkylamine base, and water.
- This method highlights a potentially simpler approach for synthesizing complex organic molecules without the need for additional ligands.
Article Abstract
[reaction: see text] A palladium-catalyzed arylation of allylic acetates followed by beta-acetoxy elimination was shown to produce Heck-type coupling products. Optimal reaction conditions employed ligand-free palladium on carbon in the presence of tetrabutylammonium chloride, a trialkylamine base, and water.
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| http://dx.doi.org/10.1021/ol051947e | DOI Listing |
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