AI Article Synopsis
- Researchers created liposomes containing 5-aminolevulinic acid (ALA) to enhance photodynamic therapy (PDT) for murine thymic lymphoma cells (EL-4) in lab experiments.
- The effectiveness of PDT improved as the liposomes decreased in size, particularly those smaller than 63.5 nm, which outperformed ALA alone in treating the cells.
- The study showed that increasing the positive charge on the liposomes did not significantly affect either PDT efficacy or the accumulation of protoporphyrin IX (PpIX) in the cells.
Article Abstract
5-Aminolevulinic acid (ALA)-containing liposomes having various average diameters and/or positive surface charges were prepared, and their photodynamic therapy (PDT) efficacy for murine thymic lymphoma cells, EL-4 cells, cultivated in vitro was investigated. The PDT efficacy for EL-4 cells and the accumulation of ALA-induced protoporphyrin IX (PpIX) in the cells increased with a decrease in the average diameter of liposomes. In particular, the ALA-containing liposomes smaller than 63.5 nm in diameter promoted the PDT efficacy in comparison with that of ALA alone. We also found no significant changes in PDT efficacy and PpIX accumulation with increasing positive surface charges of liposomes.
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| http://dx.doi.org/10.1080/03639040500216170 | DOI Listing |
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