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Delayed changes in the transcriptomic profile of cerebral arteries in a rat model of subarachnoid hemorrhage.
Exp Neurol
February 2025
Instituto de Biomedicina de Sevilla, IBIS/ Hospital Universitario Virgen del Rocío/CSIC/ Universidad de Sevilla, Sevilla, Spain; Dpto. Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Spain. Electronic address:
Aneurismal subarachnoid hemorrhage (aSAH) is a neurovascular disease characterized by blood released into the subarachnoid space due to rupture of the cerebral arteries. After the onset of bleeding, secondary associated vasospasm (VSP) remains a dramatic side effect that causes severe comorbidities. We analyzed alterations in the expression profiles of arteries from a rat model of SAH using microarray and bioinformatics approaches.
View Article and Find Full Text PDFEfficacy of intravitreal faricimab therapy for polypoidal choroidal vasculopathy: A systematic review and meta-analysis.
Acta Ophthalmol
November 2024
Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
Polypoidal choroidal vasculopathy (PCV) is an aneurismal type of macular neovascularization that show similarities with age-related macular degeneration and diseases that are part of the pachychoroid disease spectrum. Exudative changes in PCV can be treated with intravitreal anti-vascular endothelial growth factor monotherapy; however, a combination therapy with photodynamic therapy may be required. In this systematic review and meta-analysis, we evaluated the efficacy of faricimab for PCV.
View Article and Find Full Text PDF[Ruptured Stanford Type A Acute Aortic Dissection Accompanying Persistent Sciatic Artery Aneurysm: Report of a Case].
Kyobu Geka
August 2024
Division of Cardiovascular Surgery, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
Persistent sciatic artery( PSA) is a rare congenital anomaly and often results in aneurismal or occlusive changes. A 82-year-old woman was reffered with diagnosis of Stanford type A acute aortic dissection complicated cardiac tamponade. Emergent aortic arch replacement was performed.
View Article and Find Full Text PDFPaediatric Calcaneal Osteochondroma: A Case Report and a Literature Review.
Diseases
July 2024
U.O.C Traumatology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Article Synopsis
- Heel pain in children can be caused by various conditions, including fractures, diseases, and rare tumors, with this text focusing on a rare case of calcaneal exostosis.
- The case involves a 16-year-old girl with multiple cartilaginous exostoses who had painful masses in her heel, leading to a diagnosis and subsequent surgical excision of the exostosis.
- Post-surgery, the patient recovered well, being discharged in good condition, completely pain-free within 25 days, indicating effective treatment for her heel pain.
Clinical effect of external ventricular drainage under intracranial pressure monitoring in the treatment of aneurysmal subarachnoid hemorrhage patients and investigation of the mechanism of miR-146a-5p/STC1 axis in inhibiting early brain injury in aneurys.
Cell Mol Biol (Noisy-le-grand)
May 2024
Department of Intensive Care Unit, Tianjin Fourth Central Hospital, Tianjin 300142, China.
Aneurismal subarachnoid hemorrhage (aSAH) is a common disease in the neural system, with high death rate. Our study aimed to explore the clinical effect of external ventricular drainage under intracranial pressure monitoring in the treatment of patients with aSAH and investigate the role along with mechanism of miR-146a-5p in aSAH. Ninety-six aSAH patients were allocated into control group (CG) and study group (SG).
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