AI Article Synopsis
- Researchers synthesized various 6-fluoro-5-substituted-benzimidazole derivatives with indole and tetrahydronaphthalene groups to test their antioxidant properties.
- Almost all compounds demonstrated significant superoxide anion scavenging activity at a concentration of 10(-3) M, outperforming the effects of superoxide dismutase (SOD).
- Compound 11 emerged as the most effective at neutralizing DPPH stable free radicals among the tested derivatives.
Article Abstract
Some 6-fluoro-5-substituted-benzimidazole derivatives in which indole and 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene groups were attached to the 2-position of the benzimidazole ring were synthesized and tested for antioxidant properties in vitro. Almost all the synthesized compounds at the 10(-3) M concentrations showed superoxide anion scavenging activity. Compounds 5, 3, 9, 4, 17 and 13 have strong inhibitory effects on superoxide anion formation (98%, 93%, 91%, 88%, 85% and 81%, respectively) at 10(-3) M concentration and these results are better than 30 IU of superoxide dismutase (SOD) (76%). Compound 11 is the most effective scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH) stable free radical at 10(-3)M (61%) concentration.
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| http://dx.doi.org/10.1080/14756360500131706 | DOI Listing |
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