Optimal positioning of nursing in an interdisciplinary college calls for an expanded concept of succession planning that includes broad-gauged organizational and staff development strategies. The process requires time, openness to incremental change, effective leadership within the academic unit, and a well-thought-through faculty committee structure and budgetary authority. At the University of Southern Maine College of Nursing and Health Professions, succession planning has led to structural and budgetary changes and has required a flexible process, responsive to larger university priorities and fiscal challenges, that is shaped by a vision for the future of the college and of nursing.
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Three-Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction.
Adv Healthc Mater
January 2025
Department of Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers a promising solution to the persistent challenges in colorectal cancer (CRC) treatment. In this study, a "three-level nanoparticle rocket" strategy is developed by engineering CuO, a multifunctional Cu-based nanoenzyme that is photothermal and has electron transfer properties and antioxidant efficiency. CuO effectively remodels the inflammatory environment by scavenging reactive oxygen species, thereby overcoming the traditional limitations of PTT.
View Article and Find Full Text PDFDrug Development.
Alzheimers Dement
December 2024
University of California, Irvine, Irvine, CA, USA.
Background: In Alzheimer's disease (AD) clinical trials, participants must enroll with a study partner informant who accompanies them to visits and completes validated instruments. Mid-trial informant replacement (IR) has been found to impact academic trial results. We hypothesized that a similar impact would be observed in industry-sponsored trials.
View Article and Find Full Text PDFHigh grazing pressure accelerates changes in community assembly over time in a long-term grazing experiment in the desert steppe of northern China.
Oecologia
January 2025
College of Grassland, Resources and Environment, Inner Mongolia Agricultural University, 29 Ordos Rd., Hohhot, 010011, China.
Although numerous studies have shown that grazing gives rise to community succession from the communities or even species perspective, there is a lack of discussion about how grazing drives community assembly based on plant functional traits in a long-term experiment. We find different grazing intensities lead to temporal effects on trait-mediated multidimensional community assembly processes, including community-weighted trait mean (CWM), trait filtering, and trait distribution (divergence/convergence). CWM, trait filtering, and trait distribution of different traits transformed over the 16-year grazing experiment.
View Article and Find Full Text PDFChallenges in multinational rare disease clinical studies during COVID-19: regulatory assessment of cipaglucosidase alfa plus miglustat in adults with late-onset Pompe disease.
J Neurol
January 2025
John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle-upon-Tyne, UK.
PROPEL (ATB200-03; NCT03729362) compared the efficacy and safety of cipaglucosidase alfa plus miglustat (cipa + mig), a two-component therapy for late-onset Pompe disease (LOPD), versus alglucosidase alfa plus placebo (alg + pbo). The primary endpoint was change in 6-min walk distance (6MWD) from baseline to week 52. During PROPEL, COVID-19 interrupted some planned study visits and assessment windows, leading to delayed visits, make-up assessments for patients who missed ≥ 3 successive infusions before planned assessments at weeks 38 and 52, and some advanced visits (end-of-study/early-termination visits).
View Article and Find Full Text PDFThe Assessment of the Dynamics of Changes in the Torques of Redressing and Derotating Forces Acting on the Spine During Active Kyphosis-Deepening Exercises in the Dynamic Individual Stimulation and Control for Spine Device (DISC4SPINE, D4S).
J Clin Med
December 2024
Faculty of Biomedical Engineering, Silesian University of Technology, 44-100 Zabrze, Poland.
: The study aimed to assess the dynamics of changes in the torques of derotating and redressing forces acting on the apexes of deformation curvature arches during active, kyphosis-inducing exercises using the D4S device. : The study group included 12 girls aged 9 to 10 years (age X = 9.36, SD = 1.
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