We report a reappraisal of patient NT who became severely amnesic after a right temporal lobectomy for intractable epilepsy (DINSDALE et al., Neuropsychologia 1, 287, 1964 [6]). Histological examination, albeit incomplete, indicated that there was no abnormality in the resected temporal lobe. At autopsy a sclerotic lesion of the unoperated left hippocampal formation was found. This case is therefore not an exception to the general rule that a severe and global amnesic state is only observed with bilateral lesions. Her performance on a wide range of memory tests is shown to be indistinguishable from patients with an amnesic syndrome due to Korsakoff's psychosis.
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http://dx.doi.org/10.1016/0028-3932(92)90091-y | DOI Listing |
It is becoming more broadly accepted that human-based models are needed to better understand the complexities of the human nervous system and its diseases. The recently developed human brain organotypic culture model is one highly promising model that requires the involvement of neurosurgeons and neurosurgical patients. Studies have investigated the electrophysiological properties of neurons in such human tissues, but the maintenance of other cell types within explanted brain remains largely unknown.
View Article and Find Full Text PDFEpilepsia
December 2024
Department of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Objective: Stereotactic laser amygdalohippocampotomy (SLAH) is a minimally invasive procedure for mesial temporal lobe epilepsy that preserves more tissue than open procedures. As a result, although patients have better functional outcomes, more patients do not achieve seizure freedom. The rate at which this occurs is evolving with improved surgical practices.
View Article and Find Full Text PDFNeurosurgery
December 2024
Department of Neurosurgery, Korle Bu Teaching Hospital, Accra, Ghana.
Background And Objectives: Nearly one-third of individuals with epilepsy have drug-resistant epilepsy, treated most effectively with surgery. This study aims to discuss the demographic profile, surgical access, and strategies used in drug-resistant epilepsy in Africa.
Methods: A systematic review was performed using PubMed, Google Scholar, Embase, and Web of Science in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.
Neurochirurgie
December 2024
Neurosurgery Department, Fundación Instituto Neurológico de Colombia, Medellín, Colombia. Electronic address:
Objective: To analyze postoperative seizure outcomes and factors associated with unfavorable seizure control (Engel III-IV) in adults with drug-resistant unilateral mesial temporal epilepsy who underwent temporal lobectomy.
Methods: This was an observational, longitudinal, and retrospective study. A descriptive analysis of sociodemographic, clinical, and paraclinical characteristics was performed.
Acta Neurochir (Wien)
November 2024
Department of Neurosurgery, University of Chicago, Chicago, IL, USA.
Background: This study compares Selective Amygdalohippocampectomy (SAHE) and Anterior Temporal Lobectomy (ATL) for temporal lobe epilepsy (TLE), focusing on seizure control and visual field deficits (VFD). While previous research suggests potential benefits of SAHE, this meta-analysis aims to clarify the comparative effectiveness of bothprocedures.
Methods: This study adhered to PRISMA guidelines, comparing seizure outcomes and VFDs between SAHE and ATL for temporal lobe epilepsy.
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