Challenges in implementing a successful newborn cystic fibrosis screening program.

Objective: To identify necessary components of a successful cystic fibrosis (CF) newborn screening (NBS) program.

Study Design: The approach to CF NBS used by the Massachusetts NBS program was examined.

Results: Several key components were identified that should be addressed when a state has made the decision to screen, and well in advance of actual implementation. These components include (1) inclusion of CF center directors in the development process; (2) logistics of choosing a screening algorithm relative to practices in place and community wishes; (3) projections of medical service needs from specific algorithms; (4) identification of critical reporting components; (5) identification of critical follow-up components; and (6) recognition of educational needs.

Conclusions: Careful examination of a wide variety of issues is needed to ensure optimal implementation of NBS for CF.