AI Article Synopsis
- The study analyzed 1686 hospitalized cases of chronic hepatitis B (CHB) to compare clinical characteristics based on HBeAg status.
- Among the participants, 37.3% were HBeAg-negative and showed lower serum ALT and HBV DNA levels but had more advanced liver inflammation and fibrosis compared to the HBeAg-positive group.
- Ultimately, the findings highlight that HBeAg-positive CHB remains more common in Chinese patients, and those with active HBV replication experience higher liver inflammation activity.
Article Abstract
Objective: To investigate the clinical characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B (CHB).
Methods: A total of 1686 hospitalized CHB cases were analyzed retrospectively. The serum ALT values, HBV DNA levels and hepatic inflammation and fibrosis were analyzed by their serum HBeAg status.
Results: Among the 1686 cases, 628 (37.3%) were HBeAg-negative and 1058 (62.7%) were HBeAg-positive. Compared with HBeAg-positive group, HBeAg-negative group had a lower serum ALT and HBV DNA levels. However, hepatic necroinflammation grading and fibrosis staging in HBeAg-negative group were more advanced than that of HBeAg-positive group. Irrespective to serum HBeAg status, patients with serum HBV DNA less than 10(5)copies/ml, had a lower hepatic necroinflammation activity.
Conclusions: HBeAg-positive CHB is still the predominant form of CHB in Chinese patients. Compared with patients with low HBV replication, patients with active HBV replication had a higher hepatic necroinflammation activity. The liver histological grading and staging in HBeAg-negative CHB patients were more advanced than that in HBeAg-positive patients.
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