Scars are extremely problematic, especially due to their unstableness, particularly in weight bearing areas (maximum 70% of the stability of normal skin). The use of split-thickness skin grafts or meshed split-thickness grafts frequently produces poor cosmetic and functional results, full thickness skin is only available in small quantities, free tissue transfer creates severe donor site defects and is surgically challenging. INTEGRA Dermal Regeneration Template is a unique technology which allows permanent regeneration of functional autologous dermal tissue and appears as a new alternative to full-thickness skin grafting, skin expansion and even skin flaps for reconstructive surgery. We used the INTEGRA Dermal Regeneration Template in a patient with a scalped left hand and amputated fingers (Fig. 13, Ref. 10).
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Reconstruction of Back Defect from Giant Congenital Melanocytic Nevus Using Dermal Substitute Matrix.
Plast Reconstr Surg Glob Open
January 2025
From the Division of Plastic and Reconstructive Surgery, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Giant congenital melanocytic nevi are large pigmented premalignant lesions present at birth that have an associated risk of malignant transformation. Full-thickness excision of these lesions would be required to eliminate this risk. However, giant nevi can leave behind large defects that can be challenging to reconstruct.
View Article and Find Full Text PDFA Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template.
Macromol Biosci
December 2024
Biomanufacturing Technology, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore, 138669, Singapore.
Third-degree burns result in extensive damage to the skin's epidermal and dermal layers, with limited treatment options available. Currently, xenogeneic collagen-based skin grafts are used as scaffolds to integrate into the wound bed and provide a template for neodermis formation. Existing commercial products like Integra dermal templates rely on a time-consuming and variable dehydrothermal (DHT) crosslinking process.
View Article and Find Full Text PDFPediatric Reconstruction of Full-Thickness Dog Bite Scalp Avulsion with a Combination of Acellular and Matrix Products: A Case Report.
Medicina (Kaunas)
November 2024
Plastic and Maxillofacial Surgery Unit-Bambino Gesù Children Hospital-Rome, 00120 Vatican City, Vatican City State.
The reconstruction of large full-thickness scalp injuries represents a great challenge in pediatric plastic surgery. Epidermal-dermal substitutes come to the rescue when traditional surgical strategies are not suitable. Recently, the new Integra MicroMatrix UBM particulate has arisen on the market.
View Article and Find Full Text PDFDermal Substitute Integra for the Treatment of Mammalian Bite Injuries of Nose: a New Reconstructive Ladder.
Plast Reconstr Surg Glob Open
November 2024
From the Department of Plastic Reconstructive Surgery and BURNS, AORN A. Cardarelli, Napoli, Italy.
Background: Bite injuries affecting the nose are uncommon occurrences characterized by their intricate nature and potential for severe complications. These injuries, inflicted by animals such as dogs and cats, and occasionally by humans, often result in traumatic nasal defects, with the lower third of the nose being the most affected area. Current reconstructive options for nasal defects include full-thickness skin grafts, local or regional flaps, and composite grafts.
View Article and Find Full Text PDFOptimizing Myelomeningocele Repair: Assessing the Role of Synthetic Acellular Dermal Regeneration Templates in Complex Closures.
J Craniofac Surg
November 2024
Division of Plastic and Reconstructive Surgery, McGovern Medical School at the University of Texas Health Science Center.
Article Synopsis
- - The study explored the use of acellular dermal regeneration templates (ADRT) to heal myelomeningoceles in newborns, a condition that poses risks due to central nervous system infections and challenges in surgical repair.
- - A review of seven cases revealed that many patients experienced complications from previous repair attempts, leading to the need for ADRT to enhance the healing process and protect vital structures.
- - Results showed that after ADRT placement, four patients developed healthy granulation tissue within three weeks, and all wounds healed without infections, suggesting ADRT is a promising option for difficult myelomeningocele repairs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!