Objective: To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.
Method: Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.
Results: The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).
Conclusion: HPCD is an ideal solubilizer for paeonolum.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
study solubilization
8
solubility paeonolum
8
hpcd concentration
8
paeonolum
6
[the solubilization
4
solubilization 2-hydroxypropyl-beta-cyclodextrin
4
2-hydroxypropyl-beta-cyclodextrin paeonolum]
4
paeonolum] objective
4
objective study
4
solubilization 2-hydroxypropyl-beta-cyclodextrinhpcd
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!