AI Article Synopsis
- The study investigates how a novel copper(II) complex interacts with DNA using various techniques like absorption and fluorescence spectroscopy, voltammetry, and viscosity measurements.
- The results show that the copper complex causes noticeable changes in DNA properties, including reduced light absorption (hypochromism) and enhanced voltammetric responses, indicating strong binding to DNA through intercalation.
- Additionally, the copper complex promotes the cleavage of plasmid pBR322 DNA when hydrogen peroxide is present, suggesting its potential as a DNA-targeting agent.
Article Abstract
DNA-binding properties of novel copper(II) complex [Cu(l-Phe)(TATP)(H(2)O)](+), where L-Phe=L-phenylalaninate and TATP=1,4,8,9-tetra-aza-triphenylene are investigated using electronic absorption spectroscopy, fluorescence spectroscopy, voltammetry and viscosity measurement. It is found that the presence of calf thymus DNA results in a hypochromism and red shift in the electronic absorption, a quenching effect on fluorescence nature of ethidium bromide-DNA system, an enhanced response on voltammograms of [Co(phen)(3)](3+/2+)-DNA system, and an obvious change in viscosity of DNA. From absorption titration, fluorescence analysis and voltammetric measurement, the binding constant of the complex with DNA is calculated. The latter two methods reveal the stronger binding of [Cu(l-Phe)(TATP)(H(2)O)](+) complex to double strand DNA by the moderate intercalation than [Co(phen)(3)](3+). Such a binding induces the cleavage of plasmid pBR322 DNA in the presence of H(2)O(2).
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| http://dx.doi.org/10.1016/j.jinorgbio.2005.08.005 | DOI Listing |
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